Evidence map›Paper›PMID 35203245›Full record

ArticleCells2022

Anti-microRNA-21 Therapy on Top of ACE Inhibition Delays Renal Failure in Alport Syndrome Mouse Models.

Diana Rubel, Joseph Boulanger, Florin Craciun, Ethan Y Xu, Yanqin Zhang, Lucy Phillips, Michelle Callahan, William Weber, Wenping Song, Nicholas Ngai and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 38 citations in OpenAlex.

  1. New therapeutic hope for rare podocytopathies.Pediatric nephrology (Berlin, Germany) · 2026
    Review
  2. Review
  3. Article
  4. Are RNA Therapies a Solid Foundation or a Frontier Yet to Be Conquered?International journal of molecular sciences · 2026
    Review
  5. Review
  6. Review
  7. Review
  8. Treatment Approaches for Alport Syndrome.Journal of the American Society of Nephrology : JASN · 2026
    Review
  9. Review
  10. RNA Therapies in Cardio-Kidney-Metabolic Syndrome: Advancing Disease Management.Journal of cardiovascular translational research · 2025
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Personalized Antifibrotic Therapy in CKD Progression.Journal of personalized medicine · 2024
    Review
  17. Targeted therapeutic strategies for the kidney.Expert opinion on therapeutic targets · 2024
    Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 2 countries.

Diana RubelClinic for Nephrology and Rheumatology, University Medical Center Goettingen, 37075 Goettingen, Germany.
Joseph BoulangerSanofi Research & Development, Cambridge, MA 02142, USA.
Florin CraciunSanofi-Genzyme Research and Development, Framingham, MA 02118, USA.
Ethan Y XuSanofi-Genzyme Research and Development, Framingham, MA 02118, USA.ORCID 0000-0002-7496-0835
Yanqin ZhangClinic for Nephrology and Rheumatology, University Medical Center Goettingen, 37075 Goettingen, Germany.
Lucy PhillipsSanofi-Genzyme Research and Development, Framingham, MA 02118, USA.
Michelle CallahanSanofi-Genzyme Research and Development, Framingham, MA 02118, USA.
William WeberSanofi-Genzyme Research and Development, Framingham, MA 02118, USA.
Wenping SongSanofi-Genzyme Research and Development, Framingham, MA 02118, USA.
Nicholas NgaiSanofi-Genzyme Research and Development, Framingham, MA 02118, USA.
Nikolay O BukanovSanofi-Genzyme Research and Development, Framingham, MA 02118, USA.
Xingyi ShiSanofi-Genzyme Research and Development, Framingham, MA 02118, USA.ORCID 0000-0001-7487-5764
Ali HaririSanofi-Genzyme, Clinical Development, Cambridge, MA 02142, USA.
Hervé HussonSanofi-Genzyme Research and Development, Framingham, MA 02118, USA.ORCID 0000-0001-8829-5672
Oxana Ibraghimov-BeskrovnayaSanofi-Genzyme Research and Development, Framingham, MA 02118, USA.
Shiguang LiuSanofi-Genzyme, Clinical Development, Cambridge, MA 02142, USA.
Oliver GrossClinic for Nephrology and Rheumatology, University Medical Center Goettingen, 37075 Goettingen, Germany.ORCID 0000-0002-8390-8852
Genesys (United States) · USAbbVie (United States) · USBoston Biomedical Research Institute · USJanssen (United States) · USPeking University · CNSanofi (United States) · USTakeda (United States) · US

Funding

Alport Syndrome Foundation to Oliver Gross
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angiotensin-Converting Enzyme InhibitorsMicroRNAsNephritis, HereditaryRenal InsufficiencyAnimalsAntagomirsCollagen Type IVDisease Models, AnimalFibrosisHumansMiceMice, KnockoutAngiotensin-Converting Enzyme InhibitorsAntagomirsCollagen Type IVMicroRNAsMIRN21 microRNA, mouseAlport syndromehereditary kidney diseaseskidney therapiesmicroRNA-21nephroprotectionpodocytopathiesrenal fibrosistype IV collagen

Identifiers

PMID35203245
PMCPMC8869926
OpenAlexW4211262954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.