ArticleCerebral cortex (New York, N.Y. : 1991)2022
Spike-timing-dependent plasticity rewards synchrony rather than causality.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- An integratediScience · 2026Article
- A Bidirectional Neural Interface With Direct On-Device Neuromorphic Decoding for Closed-Loop Optogenetics.bioRxiv : the preprint server for biology · 2026Article
- Metaplastic sleep regulation inbioRxiv : the preprint server for biology · 2026Article
- Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025Review
- Ultrastructural analysis of synapses after induction of spike-timing-dependent plasticity.Cell reports methods · 2025Article
- Cryo-EM structure of a blue-shifted channelrhodopsin from Klebsormidium nitens.Nature communications · 2025Article
- A unified framework to model synaptic dynamics during the sleep-wake cycle.PLoS biology · 2025Article
- Ex vivo cortical circuits learn to predict and spontaneously replay temporal patterns.Nature communications · 2025Article
- Review
- Large-scale interactions in predictive processing: oscillatory versus transient dynamics.Trends in cognitive sciences · 2025Review
- Pathophysiological Insights and Multimodal Interventions in Chronic Tinnitus, Anxiety, and Sleep Disorders.Nature and science of sleep · 2025Review
- Opportunities and Challenges of Brain-on-a-Chip Interfaces.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Evolving alterations of structural organization and functional connectivity in feedforward neural networks after induced P301L tau mutation.The European journal of neuroscience · 2024Article
- Optogenetics and Targeted Gene Therapy for Retinal Diseases: Unravelling the Fundamentals, Applications, and Future Perspectives.Journal of clinical medicine · 2024Review
- Practical considerations in an era of multicolor optogenetics.Frontiers in cellular neuroscience · 2023Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Spike-timing-dependent plasticity (STDP) is a candidate mechanism for information storage in the brain, but the whole-cell recordings required for the experimental induction of STDP are typically limited to 1 h. This mismatch of time scales is a long-standing weakness in synaptic theories of memory. Here we use spectrally separated optogenetic stimulation to fire precisely timed action potentials (spikes) in CA3 and CA1 pyramidal cells. Twenty minutes after optogenetic induction of STDP (oSTDP), we observed timing-dependent depression (tLTD) and timing-dependent potentiation (tLTP), depending on the sequence of spiking. As oSTDP does not require electrodes, we could also assess the strength of these paired connections three days later. At this late time point, late tLTP was observed for both causal (CA3 before CA1) and anticausal (CA1 before CA3) timing, but not for asynchronous activity patterns (Δt = 50 ms). Blocking activity after induction of oSTDP prevented stable potentiation. Our results confirm that neurons wire together if they fire together, but suggest that synaptic depression after anticausal activation (tLTD) is a transient phenomenon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.