Evidence map›Paper›PMID 35202984›Full record

ReviewBiosensors & bioelectronics2022

Isothermal amplification-assisted diagnostics for COVID-19.

Mariarita De Felice, Mariarosaria De Falco, Daniele Zappi, Amina Antonacci, Viviana Scognamiglio

Abstract readReview
In one paragraph

Review in Biosensors & bioelectronics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Simultaneous detection of SARS-CoV-2 proteins and nucleic acids by coupling PNIPAM with circle-to-circle amplification.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2026
    Article
  5. Establishment and application of multiple cross displacement amplification coupled with lateral flow biosensor (MCDA-LFB) for visual and rapid detection of Candida glabrata.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. [Implementation of isotermic PCR for detection of SARS-CoV-2 virus].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mariarita De FeliceInstitute of Bioscience and BioResources, National Research Council, Department of Biology, Agriculture and Food Science, Via P. Castellino 111, 80100, Naples, Italy.
Mariarosaria De FalcoInstitute of Bioscience and BioResources, National Research Council, Department of Biology, Agriculture and Food Science, Via P. Castellino 111, 80100, Naples, Italy.
Daniele ZappiInstitute of Crystallography, National Research Council, Department of Chemical Sciences and Materials Technologies, Via Salaria km 29.300, 00015, Monterotondo, Rome, Italy.
Amina AntonacciInstitute of Crystallography, National Research Council, Department of Chemical Sciences and Materials Technologies, Via Salaria km 29.300, 00015, Monterotondo, Rome, Italy.
Viviana ScognamiglioInstitute of Crystallography, National Research Council, Department of Chemical Sciences and Materials Technologies, Via Salaria km 29.300, 00015, Monterotondo, Rome, Italy. Electronic address: viviana.scognamiglio@ic.cnr.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The scenery of molecular diagnostics for infectious diseases is rapidly evolving to respond to the COVID-19 epidemic. The sensitivity and specificity of diagnostics, along with speed and accuracy, are crucial requirements for effective analytical tools to address the disease spreading around the world. Emerging diagnostic devices combine the latest trends in isothermal amplification methods for nucleic acids with state-of-the-art biosensing systems, intending to bypass roadblocks encountered in the last 2 years of the pandemic. Isothermal nucleic acid amplification is a simple procedure that quickly and efficiently accumulates nucleic acid sequences at a constant temperature, without the need for sophisticated equipment. The integration of isothermal amplification into portable biosensing devices confers high sensitivity and improves screening at the point of need in low-resource settings. This review reports the latest trends reached in this field with the latest examples of isothermal amplification-powered biosensors for detecting SARS-CoV-2, with different configurations, as well as their intrinsic advantages and disadvantages.

Indexed as

Biosensing TechniquesCOVID-19Nucleic AcidsHumansMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesRNA, ViralSARS-CoV-2Sensitivity and SpecificityNucleic AcidsRNA, ViralBiosensorsHigh throughputIsothermal amplificationSARS-CoV-2 diagnosticsSensitive and specific screening

Identifiers

PMID35202984
PMCPMC8849862

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.