Evidence map›Paper›PMID 35202613›Full record

ArticleJournal of neuroscience methods2022

In vivo MRI evaluation of anterograde manganese transport along the visual pathway following whole eye transplantation.

Chiaki Komatsu, Yolandi van der Merwe, Lin He, Anisha Kasi, Jeffrey R Sims, Maxine R Miller, Ian A Rosner, Neil J Khatter, An-Jey A Su, Joel S Schuman and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroscience methods, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Monitoring outcomes of the first human whole eye allotransplant.Documenta ophthalmologica. Advances in ophthalmology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Chiaki KomatsuDepartment of Plastic and Reconstructive Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Yolandi van der MerweDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Lin HeDepartment of Plastic and Reconstructive Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Department of Plastic, Aesthetic & Maxillofacial Surgery, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Anisha KasiDepartment of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States.
Jeffrey R SimsDepartment of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States.
Maxine R MillerDepartment of Plastic and Reconstructive Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Ian A RosnerDepartment of Plastic and Reconstructive Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States.
Neil J KhatterDivision of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado, Denver, CO, United States; William Beaumont School of Medicine, Oakland University, Rochester, MI, United States.
An-Jey A SuDepartment of Plastic and Reconstructive Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado, Denver, CO, United States.
Joel S SchumanDepartment of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States; Neuroscience Institute, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States; Center for Neural Science, College of Arts and Science, New York University, New York, NY, United States; Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY, United States.
Kia M WashingtonDepartment of Plastic and Reconstructive Surgery, Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Division of Plastic and Reconstructive Surgery, Department of Surgery, University of Colorado, Denver, CO, United States; Veterans Administration Pittsburgh Healthcare System, Pittsburgh, PA, United States.
Kevin C ChanDepartment of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States; Department of Ophthalmology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States; Neuroscience Institute, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States; Center for Neural Science, College of Arts and Science, New York University, New York, NY, United States; Department of Biomedical Engineering, Tandon School of Engineering, New York University, New York, NY, United States; Department of Radiology, NYU Grossman School of Medicine, NYU Langone Health, New York University, New York, NY, United States. Electronic address: chuenwing.chan@fulbrightmail.org.
University of Pittsburgh · USNew York University · USUniversity of Colorado Denver · US

Funding

Virus Production and Manipulation of Protein/Gene Expression ModuleP30EY008098 · NEI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Yuanyuan Chen · 1989 to 2026
$17.8M
Novel Glaucoma Diagnostics for Structure and Function - Renewal - 1R01EY013178 · NEI · WILLS EYE HEALTH SYSTEM · PI Joel S Schuman · 2000 to 2026
$17.5M
Glaucoma Neuroimaging in Humans and Experimental Animal ModelsR01EY028125 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAN, KEVIN C · 2017 to 2021
$2.2M
NEI NIH HHS P30 EY008098NEI NIH HHS R01 EY013178NEI NIH HHS R01 EY028125
6 · The paper itself

Abstract

backgroundSince adult mammalian retinal ganglion cells cannot regenerate after injury, we have recently established a whole-eye transplantation (WET) rat model that provides an intact optical system to investigate potential surgical restoration of irreversible vision loss. However, it remains to be elucidated whether physiological axoplasmic transport exists in the transplanted visual pathway. NEW

methodWe developed an in vivo imaging model system to assess WET integration using manganese-enhanced magnetic resonance imaging (MEMRI) in rats. Since Mn

resultsNo significant intraocular pressure difference was found between native and transplanted eyes, whereas comparable manganese enhancement was observed between native and transplanted intraorbital optic nerves, suggesting the presence of anterograde manganese transport after WET. No enhancement was detected across the coaptation site in the higher visual areas of the recipient brain. COMPARISON WITH EXISTING

methodsExisting imaging methods to assess WET focus on either the eye or local optic nerve segments without direct visualization and longitudinal quantification of physiological transport along the transplanted visual pathway, hence the development of in vivo MEMRI.

conclusionOur established imaging platform indicated that essential physiological transport exists in the transplanted optic nerve after WET. As neuroregenerative approaches are being developed to connect the transplanted eye to the recipient's brain, in vivo MEMRI is well-suited to guide strategies for successful WET integration for vision restoration.

Indexed as

ManganeseVisual PathwaysAnimalsContrast MediaMagnetic Resonance ImagingMammalsOptic NerveRatsContrast MediaManganeseAnterograde transportMagnetic resonance imagingManganeseNeuroregenerationOptic nerveWhole-eye transplantation

Identifiers

PMID35202613
PMCPMC8940646
OpenAlexW4213022526

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.