Evidence map›Paper›PMID 35202532›Full record

ArticleEmerging infectious diseases2022

Relationship of SARS-CoV-2 Antigen and Reverse Transcription PCR Positivity for Viral Cultures.

Dustin W Currie, Melisa M Shah, Phillip P Salvatore, Laura Ford, Melissa J Whaley, Jennifer Meece, Lynn Ivacic, Natalie J Thornburg, Azaibi Tamin, Jennifer L Harcourt and 13 more

Abstract read
In one paragraph

Article in Emerging infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19: Antigen Testing (January 2023).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Guideline
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. SARS-CoV-2 viral load and shedding kinetics.Nature reviews. Microbiology · 2023
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. COVID-19 isolation strategies: What have we learned.Travel medicine and infectious disease
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Dustin W Currie
Melisa M Shah
Phillip P Salvatore
Laura Ford
Melissa J Whaley
Jennifer Meece
Lynn Ivacic
Natalie J Thornburg
Azaibi Tamin
Jennifer L Harcourt
Jennifer Folster
Magdalena Medrzycki
Shilpi Jain
Phili Wong
Kimberly Goffard
Douglas Gieryn
Juliana Kahrs
Kimberly Langolf
Tara Zochert
Christopher H Hsu
Hannah L Kirking
Jacqueline E Tate
CDC COVID-19 Response Epidemiology Field Studies Team1

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We assessed the relationship between antigen and reverse transcription PCR (RT-PCR) test positivity and successful virus isolation. We found that antigen test results were more predictive of virus recovery than RT-PCR results. However, virus was isolated from some antigen-negative and RT-PCR‒positive paired specimens, providing support for the Centers for Disease Control and Prevention antigen testing algorithm.

Indexed as

COVID-19Reverse TranscriptionAntigens, ViralHumansPolymerase Chain ReactionSARS-CoV-2Sensitivity and SpecificityAntigens, Viralcoronavirus diseasecoronavirusesCOVID-19cycle thresholdrapid antigen testrespiratory infectionsreverse transcription PCRSARS-CoV-2severe acute respiratory syndrome coronavirus 2viral culturesviruseszoonoses

Identifiers

PMID35202532
PMCPMC8888206

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.