Evidence map›Paper›PMID 35202527›Full record

ArticleEmerging infectious diseases2022

Novel Hendra Virus Variant Detected by Sentinel Surveillance of Horses in Australia.

Edward J Annand, Bethany A Horsburgh, Kai Xu, Peter A Reid, Ben Poole, Maximillian C de Kantzow, Nicole Brown, Alison Tweedie, Michelle Michie, John D Grewar and 23 more

Open access · diamondAbstract read
In one paragraph

Article in Emerging infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 63 citations in OpenAlex.

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  20. The Genetic Diversity of Nipah Virus Across Spatial Scales.The Journal of infectious diseases · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Edward J Annand
Bethany A Horsburgh
Kai Xu
Peter A Reid
Ben Poole
Maximillian C de Kantzow
Nicole Brown
Alison Tweedie
Michelle Michie
John D Grewar
Anne E Jackson
Nagendrakumar B Singanallur
Karren M Plain
Karan Kim
Mary Tachedjian
Brenda van der Heide
Sandra Crameri
David T Williams
Cristy Secombe
Eric D Laing
Spencer Sterling
Lianying Yan
Louise Jackson
Cheryl Jones
Raina K Plowright
Alison J Peel
Andrew C Breed
Ibrahim Diallo
Navneet K Dhand
Philip N Britton
Christopher C Broder
Ina Smith
John-Sebastian Eden

Funding

Project 3 - USUHSU19AI142764 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI BRODER, CHRISTOPHER C · 2019 to 2023
$24.6M
NIAID NIH HHS U19 AI142764
6 · The paper itself

Abstract

We identified and isolated a novel Hendra virus (HeV) variant not detected by routine testing from a horse in Queensland, Australia, that died from acute illness with signs consistent with HeV infection. Using whole-genome sequencing and phylogenetic analysis, we determined the variant had ≈83% nt identity with prototypic HeV. In silico and in vitro comparisons of the receptor-binding protein with prototypic HeV support that the human monoclonal antibody m102.4 used for postexposure prophylaxis and current equine vaccine will be effective against this variant. An updated quantitative PCR developed for routine surveillance resulted in subsequent case detection. Genetic sequence consistency with virus detected in grey-headed flying foxes suggests the variant circulates at least among this species. Studies are needed to determine infection kinetics, pathogenicity, reservoir-species associations, viral-host coevolution, and spillover dynamics for this virus. Surveillance and biosecurity practices should be updated to acknowledge HeV spillover risk across all regions frequented by flying foxes.

Indexed as

ChiropteraHendra VirusHenipavirus InfectionsHorse DiseasesAnimalsAustraliaHorsesPhylogenySentinel Surveillancecentral nervous systemHendra henipavirusHendra virushorse diseasesmeningitis/encephalitisOne HealthPCRRNA sequencingsentinel speciessentinel surveillancesyncytiasyndromic surveillancetransdisciplinary researchvasculitisviral encephalitisviruseswhole-genome sequencingzoonoses

Identifiers

PMID35202527
PMCPMC8888208
OpenAlexW4213371317

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.