ArticleJournal of clinical laboratory analysis2022
The role of platelet parameters for the diagnosis of preeclampsia among pregnant women attending at the University of Gondar Comprehensive Specialized Hospital antenatal care unit, Gondar, Ethiopia.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 13 citations in OpenAlex.
- Pooled it
- Preeclampsia has an association with both platelet count and mean platelet volume: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Platelet Count as a Marker of Disease Severity in Pregnancy-Induced Hypertension: A Cross-Sectional Study.Cureus · 2026Article
- The association of maternal serum parameters with pregnancy induced hypertension in Chinese population.PloS one · 2026Observational
- Diagnostic and prognostic role of platelet indices in pre-eclampsia: Insights from a hospital-based study in Eastern part of India.Journal of education and health promotion · 2026Article
- The Thrombopoietic Signature of Preeclampsia: Diagnostic and Monitoring Insights from the Immature Platelet Fraction.Diagnostics (Basel, Switzerland) · 2025Article
- Role of platelet-related parameters in prediction of development and severity of preeclampsia (PE): an observational prospective cohort study.SAGE open medicine · 2025Article
- Potential Predictive Value of Platelet Parameters in Preeclampsia.Women's health reports (New Rochelle, N.Y.) · 2024Article
- Clinical value of mean platelet volume in predicting and diagnosing pre-eclampsia: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2023Review
- A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status.Life (Basel, Switzerland) · 2022Article
- The role of platelet parameters for the diagnosis of preeclampsia among pregnant women attending at the University of Gondar Comprehensive Specialized Hospital antenatal care unit, Gondar, Ethiopia.Journal of clinical laboratory analysis · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreeclampsia (PE) is a pregnancy-related illness characterized by high blood pressure (BP) and proteinuria after the 20th gestational week (GW). Platelet (PLT) parameter changes are the common hematological abnormalities observed in PE patients. The main aim of this study was to assess the role of PLT parameters for PE diagnosis among pregnant women.
methodsA comparative cross-sectional study was conducted at the University of Gondar Specialized Hospital. A total of 126 pregnant women (63 normotensive [NT] and 63 PE) were recruited using a convenient sampling method. Three milliliter blood was collected from each participant, and PLT parameters were determined using Sysmex XS-500i analyzer. An independent t-test supplemented with receiver-operating characteristics (ROC) were used for comparisons and diagnostic value of PLT parameters between the study groups.
resultsPlatelet count (PC) was significantly lower in the PE group compared to that in the NT group, whereas mean platelet volume (MPV), platelet large cell ratio (P-LCR), and platelet distribution width (PDW) were significantly higher in PE. MPV had the largest area under the curve (AUC) [0.91: 95% CI; 0.85-0.96] followed by PC [0.79: 95% CI; 0.72-0.87]. MPV can differentiate PE patients from NT pregnant women at cut-off value ≥12.10 fl (84.1% sensitivity and 87.3% specificity) while PC can indicate PE at a cut-off value ≤176.5 × 10
conclusionA decreased PC and an increased MPV, P-LCR, and PDW can be used as a simple, cost-effective, quick, and reliable method of PE screening. Of them, MPV is the best indicator of PE.
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