Evidence map›Paper›PMID 35202426›Full record

Trial reportPloS one2022

Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson's Disease.

Kati Valkonen, Jyrki P Mäkelä, Katja Airaksinen, Jussi Nurminen, Riku Kivisaari, Hanna Renvall, Eero Pekkonen

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Kati ValkonenDepartment of Neurology, Helsinki University Hospital, Finland and Department of Clinical Neurosciences (Neurology), University of Helsinki, Helsinki, Finland.
Jyrki P MäkeläBioMag Laboratory, Helsinki University Hospital Medical Imaging Center, Helsinki University Hospital, Helsinki University and Aalto University School of Science, Helsinki, Finland.
Katja AiraksinenDepartment of Neurology, Helsinki University Hospital, Finland and Department of Clinical Neurosciences (Neurology), University of Helsinki, Helsinki, Finland.
Jussi NurminenBioMag Laboratory, Helsinki University Hospital Medical Imaging Center, Helsinki University Hospital, Helsinki University and Aalto University School of Science, Helsinki, Finland.
Riku KivisaariDepartment of Neurosurgery, Helsinki University Hospital, Helsinki, Finland.
Hanna RenvallBioMag Laboratory, Helsinki University Hospital Medical Imaging Center, Helsinki University Hospital, Helsinki University and Aalto University School of Science, Helsinki, Finland.ORCID 0000-0001-7589-7826
Eero PekkonenDepartment of Neurology, Helsinki University Hospital, Finland and Department of Clinical Neurosciences (Neurology), University of Helsinki, Helsinki, Finland.ORCID 0000-0003-1621-8752
University of Helsinki · FIHelsinki University Hospital · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep brain stimulation (DBS) has proven its clinical efficacy in Parkinson's disease (PD), but its exact mechanisms and cortical effects continue to be unclear. Subthalamic (STN) DBS acutely modifies auditory evoked responses, but its long-term effect on auditory cortical processing remains ambiguous. We studied with magnetoencephalography the effect of long-term STN DBS on auditory processing in patients with advanced PD. DBS resulted in significantly increased contra-ipsilateral auditory response latency difference at ~100 ms after stimulus onset compared with preoperative state. The effect is likely due to normalization of neuronal asynchrony in the auditory pathways. The present results indicate that STN DBS in advanced PD patients has long-lasting effects on cortical areas outside those confined to motor processing. Whole-head magnetoencephalography provides a feasible tool to study motor and non-motor neural networks in PD, and to track possible changes related to cortical reorganization or plasticity induced by DBS.

Indexed as

Auditory PerceptionDeep Brain StimulationSubthalamic NucleusAdultAgedEvoked Potentials, AuditoryFemaleFollow-Up StudiesHumansMaleMiddle AgedParkinson DiseaseSurveys and Questionnaires

Identifiers

PMID35202426
PMCPMC8870490
OpenAlexW4213413812

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.