ArticlePLoS computational biology2022
Measuring the repertoire of age-related behavioral changes in Drosophila melanogaster.
Article in PLoS computational biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 26 citations in OpenAlex.
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- Using timescale as a state coordinate reveals the metastable geometry of behavior.bioRxiv : the preprint server for biology · 2026Article
- Conserved trajectories of age-related thigmotaxis across insects and mammals reveal the house cricket as a scalable model for behavioral aging.GeroScience · 2026Article
- Lifelong behavioral screen reveals an architecture of vertebrate aging.Science (New York, N.Y.) · 2026Article
- Interspecific Conformity and Asymmetric Behavioral Convergence inEcology and evolution · 2026Article
- Age-related degradation of behavioral and network features ofFrontiers in aging neuroscience · 2026Article
- Implications of hierarchical Markov models of behavior: on irreversibility, predictability, and dimensionality.Proceedings of the ... Conference on Cognitive Computational Neuroscience · 2026Article
- Life-long behavioral screen reveals an architecture of vertebrate aging.bioRxiv : the preprint server for biology · 2025Article
- Age-related degradation of behavioral and network features ofbioRxiv : the preprint server for biology · 2025Article
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- Profiling mouse behavior with computational tools to assess age-dependent differences in associative learning.Cell reports methods · 2025Article
- Genetic and Pharmacological Inhibition of Metabotropic Glutamate Receptor Signalling Extends Lifespan in Drosophila.Aging cell · 2025Article
- Capturing continuous, long timescale behavioral changes in Drosophila melanogaster postural data.PLoS computational biology · 2025Article
- Mapping the developmental structure of stereotyped and individual-unique behavioral spaces in C. elegans.Cell reports · 2024Article
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- Aging in zebrafish is associated with reduced locomotor activity and strain dependent changes in bottom dwelling and thigmotaxis.PloS one · 2024Article
- Fluctuating landscapes and heavy tails in animal behavior.bioRxiv : the preprint server for biology · 2023Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Aging affects almost all aspects of an organism-its morphology, its physiology, its behavior. Isolating which biological mechanisms are regulating these changes, however, has proven difficult, potentially due to our inability to characterize the full repertoire of an animal's behavior across the lifespan. Using data from fruit flies (D. melanogaster) we measure the full repertoire of behaviors as a function of age. We observe a sexually dimorphic pattern of changes in the behavioral repertoire during aging. Although the stereotypy of the behaviors and the complexity of the repertoire overall remains relatively unchanged, we find evidence that the observed alterations in behavior can be explained by changing the fly's overall energy budget, suggesting potential connections between metabolism, aging, and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.