ArticleToxins2022
ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during
Open access · goldAbstract readComparative Study
In one paragraph
Article in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.1field-weighted citation impact, top 10% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
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- Molecular epidemiological association between antimicrobial resistance characteristics and type III secretion system in carbapenem-resistantFrontiers in cellular and infection microbiology · 2026Article
- The KEAP1/NRF2 axis controls LPS-induced oxidative stress, inflammasome activation and caspase-1 activity in human endothelial cells.PloS one · 2026Article
- Whole-genome sequencing reveals resistance mechanisms and molecular epidemiology of carbapenem-resistant Pseudomonas aeruginosa bloodstream infections.BMC microbiology · 2025Article
- Mechanistic blockade ofAntimicrobial agents and chemotherapy · 2025Article
- Multidrug-resistant Pseudomonas aeruginosa in immunocompromised cancer patients: epidemiology, antimicrobial resistance, and virulence factors.BMC infectious diseases · 2025Article
- Molecular characterization of serotype and virulence genes ofJournal of medical microbiology · 2025Article
- The role of programmed cell death in organ dysfunction induced by opportunistic pathogens.Critical care (London, England) · 2025Review
- A narrative review on lung injury: mechanisms, biomarkers, and monitoring.Critical care (London, England) · 2024Review
- Amyloid-β and caspase-1 are indicators of sepsis and organ injury.ERJ open research · 2024Article
- Involvement of Pore Formation and Osmotic Lysis in the Rapid Killing of Gamma Interferon-Pretreated C166 Endothelial Cells byTropical medicine and infectious disease · 2022Article
- Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics.Signal transduction and targeted therapy · 2022Review
- Role of Host and Bacterial Lipids inFrontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 1 country.
Kierra S HardyDepartment of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Amanda N TuckeyDepartment of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.ORCID 0000-0002-2778-8753
Phoibe RenemaCenter for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.ORCID 0000-0003-0230-7068
Mita PatelCenter for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Abu-Bakr Al-MehdiCenter for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Domenico SpadaforaFlow Cytometry Core Lab, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Cody A SchlumpfDepartment of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Robert A BarringtonDepartment of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Mikhail F AlexeyevCenter for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Troy StevensCenter for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Jean-Francois PittetDepartment of Anesthesiology and Perioperative Medicine, Birmingham School of Medicine, University of Alabama, Birmingham, AL 35294, USA.
Brant M WagenerDepartment of Anesthesiology and Perioperative Medicine, Birmingham School of Medicine, University of Alabama, Birmingham, AL 35294, USA.ORCID 0000-0001-7889-1526
Jon D SimmonsCenter for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
Diego F AlvarezCenter for Lung Biology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.ORCID 0000-0001-8244-629X
Jonathon P AudiaDepartment of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile, AL 36688, USA.
University of South Alabama · USUniversity of Alabama at Birmingham · USHarvard University · USSam Houston State University · US
Funding
T-type Calcium Channels and von Willebrand Factor ReleaseP01HL066299 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI LEAVESLEY, SILAS JOSIAH · 2001 to 2022
$34.6MMouse models for mitochondrial disorders caused by mutations in mtDNAR01OD010944 · OD · UNIVERSITY OF SOUTH ALABAMA · PI ALEXEYEV, MIKHAIL F., WALLACE, DOUGLAS C · 2012 to 2020
$2.6MCaspase-1, the Microvascular Endothelium, and InfectionR01HL118334 · NHLBI · UNIVERSITY OF SOUTH ALABAMA · PI ALVAREZ, DIEGO F., AUDIA, JONATHON PETER · 2015 to 2019
$2.0MSeahorse XFe24 Extracellular Flux AnalyzerS10OD025089 · OD · UNIVERSITY OF SOUTH ALABAMA · PI ALEXEYEV, MIKHAIL F. · 2019 to 2019
$164kNHLBI NIH HHS P01 HL066299NHLBI NIH HHS R01 HL118334NIH HHS R01 OD010944NIH HHS S10 OD025089
Abstract
The Gram-negative, opportunistic pathogen
Indexed as
Bacterial ProteinsCaspase 1Cell DeathChemical and Drug Induced Liver InjuryEndothelial CellsGenetic VariationGenotypeHumansInflammationPseudomonas aeruginosaPseudomonas InfectionsBacterial ProteinsCaspase 1caspase-1ExoUmitochondriapneumoniaPseudomonas aeruginosapulmonary endothelial cellsreactive oxygen speciessepsisstress responses
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.