Evidence map›Paper›PMID 35202156›Full record

ArticleToxins2022

Crystal Structures of Botulinum Neurotoxin Subtypes A4 and A5 Cell Binding Domains in Complex with Receptor Ganglioside.

Kyle S Gregory, Otsile O Mojanaga, Sai Man Liu, K Ravi Acharya

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Crystal Structures of theInternational journal of molecular sciences · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Kyle S GregoryDepartment of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Otsile O MojanagaDepartment of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Sai Man LiuProtein Sciences Department, Ipsen Bioinnovation Limited, 102 Park Drive, Milton Park, Abingdon OX14 4RY, UK.ORCID 0000-0001-6359-0229
K Ravi AcharyaDepartment of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.ORCID 0000-0002-3009-4058
University of Bath · GBIpsen (United Kingdom) · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Botulinum neurotoxins (BoNT) cause the potentially fatal neuroparalytic disease botulism that arises due to proteolysis of a SNARE protein. Each BoNT is comprised of three domains: a cell binding domain (H

Indexed as

Molecular StructureBotulinum Toxins, Type ABotulismCarrier ProteinsCrystallography, X-RayGangliosidesHumansNeuromuscular JunctionNeuronsBotulinum Toxins, Type ACarrier ProteinsGangliosidesbotulinum neurotoxincell binding domaincrystal structureganglioside bindingsubtypes A4 and A5

Identifiers

PMID35202156
PMCPMC8876736
OpenAlexW4210977978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.