Evidence map›Paper›PMID 35202132›Full record

Observational studyToxins2022

Comprehensive Assessment of the Time Course of Biomechanical, Electrophysiological and Neuro-Motor Effects after Botulinum Toxin Injections in Elbow Flexors of Chronic Stroke Survivors with Spastic Hemiplegia: A Cross Sectional Observation Study.

Yen-Ting Chen, Yang Liu, Chuan Zhang, Elaine Magat, Ping Zhou, Yingchun Zhang, Sheng Li

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 3 pooled it
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 syntheses or guidelines pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Relationship Between Spinal Reflexes and Spastic Movement Disorders.Physical medicine and rehabilitation clinics of North America · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yen-Ting ChenDepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Yang LiuDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
Chuan ZhangDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
Elaine MagatDepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Ping ZhouFaculty of Biomedical and Rehabilitation Engineering, University of Health and Rehabilitation Sciences, Qingdao 266024, China.
Yingchun ZhangDepartment of Biomedical Engineering, University of Houston, Houston, TX 77204, USA.
Sheng LiDepartment of Physical Medicine and Rehabilitation, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
University of Houston · USMemorial Hermann Institute for Rehabilitation and Research Foundation · USNortheastern State University · USThe University of Texas Health Science Center at Houston · US

Funding

Imaging of 3D Innervation Zone Distribution in Spastic Muscles from High-Density Surface EMG RecordingsR21HD090453 · NICHD · UNIVERSITY OF HOUSTON · PI LI, SHENG, ZHANG, YINGCHUN · 2017 to 2018
$434k
NIH HHS NIH HD090453
6 · The paper itself

Abstract

Botulinum neurotoxin (BoNT) is commonly used to manage focal spasticity in stroke survivors. This study aimed to a perform comprehensive assessment of the effects of BoNT injection. Twelve stroke subjects with spastic hemiplegia (age: 52.0 ± 10.1 year; 5 females) received 100 units of BoNT to the spastic biceps brachii muscles. Clinical, biomechanical, electrophysiological, and neuro-motor assessments were performed one week (wk) before (pre-injection), 3 weeks (wks) after, and 3 months (mons) after BoNT injection. BoNT injection significantly reduced spasticity, muscle strength, reflex torque, and compound muscle action potential (CMAP) amplitude of spastic elbow flexors (all

Indexed as

Action PotentialsAdultBiomechanical PhenomenaBotulinum ToxinsChronic DiseaseCross-Sectional StudiesElbowFemaleHemiplegiaHumansMaleMiddle AgedMuscle, SkeletalMuscle SpasticityNeuromuscular AgentsReflexBotulinum ToxinsNeuromuscular AgentsBotulinum toxinmotor controlspasticitystretch reflexstroke

Identifiers

PMID35202132
PMCPMC8875179
OpenAlexW4210568786

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.