Evidence map›Paper›PMID 35202128›Full record

ArticleToxins2022

Aryl Hydrocarbon Receptor Inhibition Restores Indoxyl Sulfate-Mediated Endothelial Dysfunction in Rat Aortic Rings.

Cindy Nguyen, Amanda J Edgley, Darren J Kelly, Andrew R Kompa

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Cindy NguyenDepartment of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy 3065, Australia.
Amanda J EdgleyDepartment of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy 3065, Australia.
Darren J KellyDepartment of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy 3065, Australia.
Andrew R KompaDepartment of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy 3065, Australia.ORCID 0000-0003-1002-2302
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The uremic toxin indoxyl sulfate (IS), elevated in chronic kidney disease (CKD), is known to contribute towards progressive cardiovascular disease. IS activates the aryl hydrocarbon receptor (AhR) mediating oxidative stress and endothelial dysfunction via activation of the CYP1A1 pathway. The present study examines AhR inhibition with the antagonist, CH223191, on IS-mediated impairment of vascular endothelial function and disruption of redox balance. The acute effects of IS on endothelium-dependent relaxation were assessed in aortic rings from Sprague Dawley rats exposed to the following conditions: (1) control; (2) IS (300 μM); (3) IS + CH223191 (1 μM); (4) IS + CH223191 (10 μM). Thereafter, tissues were assessed for changes in expression of redox markers. IS reduced the maximum level of endothelium-dependent relaxation (Rmax) by 42% (

Indexed as

AnimalsAorta, ThoracicAzo CompoundsCytochrome P-450 CYP1A1Endothelium, VascularGene ExpressionIndicanMaleOxidative StressPyrazolesRatsRats, Sprague-DawleyReactive Oxygen SpeciesReceptors, Aryl HydrocarbonRenal Insufficiency, ChronicVasodilation2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amideAzo CompoundsCytochrome P-450 CYP1A1IndicanPyrazolesReactive Oxygen SpeciesReceptors, Aryl Hydrocarbonaryl hydrocarbon receptorcardiovascular diseasechronic kidney diseaseendothelial dysfunctionindoxyl sulfateoxidative stress

Identifiers

PMID35202128
PMCPMC8878015
OpenAlexW4210368997

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.