Evidence map›Paper›PMID 35202069›Full record

ArticlePharmacy (Basel, Switzerland)2022

The Use of Off-Label Medications in Newborn Infants Despite an Approved Alternative Being Available-Results of a National Survey.

Alex Veldman, Eva Richter, Christian Hacker, Doris Fischer

Open access · goldAbstract read
In one paragraph

Article in Pharmacy (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Alex VeldmanDepartment of Pediatrics, Helios HSK, 65199 Wiesbaden, Germany.
Eva RichterDepartment of Pediatrics, Justus-Liebig University, 35385 Giessen, Germany.
Christian HackerPharmacy, St. Vincenz Hospital, 65549 Limburg, Germany.
Doris FischerDepartment of Pediatrics, Helios HSK, 65199 Wiesbaden, Germany.ORCID 0000-0001-9893-6744
Justus-Liebig-Universität Gießen · DEGoethe University Frankfurt · DESt. Vincenz-Krankenhaus Limburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonates continue to be treated with off-label or unlicensed drugs while in hospital. However, some medications that have previously been used in adults underwent clinical testing and licensure for use with a different indication in the neonatal and pediatric population. Almost always, the marketing of these newly approved substances in a niche indication is accompanied by a steep increase in the price of the compound. We investigated the use of the approved formulation or the cheaper off-label alternative of Ibuprofen (Pedea

Indexed as

European pediatric regulationneonateNICUoff-label drug useprescribing

Identifiers

PMID35202069
PMCPMC8877519
OpenAlexW4210669097

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.