ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022
Effects of -10° and -30° head-down tilt on cerebral blood velocity, dynamic cerebral autoregulation, and noninvasively estimated intracranial pressure.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 19 citations in OpenAlex.
- Neural Control of Tissue Perfusion: Emerging Evidence and Beyond.Current hypertension reports · 2026Review
- Head-down position after reperfusion improves cerebral ischaemic injury in rat.Stroke and vascular neurology · 2026Article
- Impact of Trendelenburg angle on perioperative outcomes during gasless vNOTES surgeries: a retrospective comparative study.BMC anesthesiology · 2026Article
- Effects of sustained Trendelenburg position on the spectral signatures of the EEG: implications for the consistency of the level of anesthesia, an observational study.Journal of clinical monitoring and computing · 2026Observational
- Cardiovascular response of children to 1 hour of microgravity simulation-a pioneering study.NPJ microgravity · 2026Article
- Reduced cerebral blood flow does not alter concurrent or post-intervention inhibitory control: evidence from a 3-h head-down tilt protocol in healthy young adults.Experimental brain research · 2026Article
- Lateralized cerebral arterial blood flow and blood pressure adaptations to short-term head-down tilt: a 4D flow MRI study with cognitive function assessment.Military Medical Research · 2026Article
- Review of microgravity's impact on cardiovascular and nervous systems in space exploration.NPJ microgravity · 2025Review
- [Risks, mechanisms, and prevention strategies for cerebrovascular diseases in lunar astronauts under deep].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025Review
- Impact of patient positioning on bleeding rate in stereotactic brain biopsies: semi-sitting versus supine position.Acta neurochirurgica · 2025Article
- Ventilatory response to head-down-tilt in healthy human subjects.Experimental physiology · 2024Article
- Investigating the effects of tilting the postural drainage lithotripsy system on cerebral blood flow, intracranial pressure, heart rate, and blood pressure.World journal of urology · 2024Article
- Quantitative ultrasound image assessment of the optic nerve subarachnoid space during 90-day head-down tilt bed rest.NPJ microgravity · 2024Article
- Postural influence on intracranial fluid dynamics: an overview.Journal of physiological anthropology · 2023Review
- Steady-state cerebral blood flow and dynamic cerebral autoregulation during neck flexion and extension in seated healthy young adults.Physiological reports · 2023Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
Steady-state cerebral blood flow (CBF) and dynamic cerebral autoregulation are reportedly maintained during -10° head-down tilt (HDT) despite slight increases in intracranial pressure (ICP). However, the higher ICP during -30° HDT may alter steady-state CBF and dynamic cerebral autoregulation. The present study hypothesized that steady-state CBF and dynamic cerebral autoregulation would be altered by higher ICP during -30° HDT than during 0° and -10° HDT. Seventeen healthy participants were positioned horizontal (0°) and in -10° HDT and -30° HDT for 10 min in random order on separate days. The arterial blood pressure waveform was obtained using a finger blood pressure device and the cerebral blood velocity waveform in the middle cerebral artery was obtained using transcranial Doppler sonography (TCD) for the last 6 min in each position. ICP was estimated using noninvasive ICP (nICP) based on TCD. Dynamic cerebral autoregulation was evaluated by spectral and transfer function analysis. Although nICP was significantly higher during -30° HDT (12.4 mmHg) than during -10° HDT (8.9 mmHg), no significant differences in steady-state mean cerebral blood velocity or transfer function gain in any frequency ranges were seen among all angles of HDT. Counter to our hypothesis, the present results suggest that steady-state CBF and dynamic cerebral autoregulation may be preserved during short-term -30° HDT despite the higher ICP compared with that during -10° HDT.
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