ReviewChemical reviews2022
Replacement of Less-Preferred Dipolar Aprotic and Ethereal Solvents in Synthetic Organic Chemistry with More Sustainable Alternatives.
Review in Chemical reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
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- Copper on Calcium Carbonate and Marble Waste as Recyclable Catalysts for Ultrasound-Assisted One-Pot Synthesis of 1,4-Disubstituted 1,2,3-Triazoles.ChemSusChem · 2026Article
- Scalable Synthesis of a Masked Thiophenol as an Air-Stable, Odorless Intermediate to the Aurora Kinase Inhibitor Tozasertib (VX-680).Organic process research & development · 2026Article
- An account on using bio-renewable solvents in organic synthesis: advances, prospects, and challenges.RSC advances · 2026Review
- A transition metal-free route toRSC advances · 2026Article
- Solvent Polarity Engineering in Low-DMF ZIF-7 Membrane Growth: Crystallization Behavior, Heterogeneous Intergrowth, and Microstructural Evolution.Molecules (Basel, Switzerland) · 2026Article
- Encapsulated droplet array for intensified micromole-scale high-throughput reaction screening.Nature communications · 2026Article
- 1,4-Pentanediol as an Alternative Biomass-Derived Medium for the Phosphine-Free Heck Coupling Reactions.ChemSusChem · 2026Article
- Merging Micellar Catalysis and C-H Activation: Silver-Free Direct Arylation of Fluoroarenes in Water.ChemSusChem · 2026Article
- When Does Machine Learning Add Value over Theory? Predicting API Solubility in Binary Mixtures with COSMO-RS and DOOIT2 Across Diverse and Homogeneous Systems.Molecules (Basel, Switzerland) · 2026Article
- Cyrene Dimethyl Acetal: Potential Alternative Solvent for Pd-Catalyzed Homogeneous Aminocarbonylation of Iodo(hetero)arene Compounds.ChemPlusChem · 2026Article
- Recent Developments in Sustainable Solubilization.ChemSusChem · 2026Article
- Recent Progress of N,N-Dimethylformamide (DMF) as Versatile Synthons in Organic Synthesis.Topics in current chemistry (Cham) · 2026Review
- Once Upon a Time Without DMF: Greener Paths in Peptide and Organic Synthesis.Molecules (Basel, Switzerland) · 2026Review
- Shaking Up Photochemistry: The Future Frontiers of Mechanophotocatalysis.ACS central science · 2026Review
- Synthesis of Polyimides, Polyamides, and Poly(Amide-Imides) in the "Green" Solvent N-Butyl-2-Pyrrolidone (TamiSolve NxG): Features, Optimization, and Versatility.International journal of molecular sciences · 2026Article
- Solvent Sustainability in Drug Discovery: Where Are We Now, and How Can We Improve?Journal of medicinal chemistry · 2025Review
- Reversible Deactivation Radical Polymerization in Biomass-Derived Solvents: Sustainable Approach in Polymer Chemistry.ACS polymers Au · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dipolar aprotic and ethereal solvents comprise just over 40% of all organic solvents utilized in synthetic organic, medicinal, and process chemistry. Unfortunately, many of the common "go-to" solvents are considered to be "less-preferable" for a number of environmental, health, and safety (EHS) reasons such as toxicity, mutagenicity, carcinogenicity, or for practical handling reasons such as flammability and volatility. Recent legislative changes have initiated the implementation of restrictions on the use of many of the commonly employed dipolar aprotic solvents such as dimethylformamide (DMF) and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.