Evidence map›Paper›PMID 35201615›Full record

ArticleThe Medical journal of Australia2022

COVID-19 vaccination in children and adolescents aged 5 years and older undergoing treatment for cancer and non-malignant haematological conditions: Australian and New Zealand Children's Haematology/Oncology Group consensus statement.

Eliska Furlong, Rishi S Kotecha, Rachel Conyers, Tracey A O'Brien, Jordan R Hansford, Leanne Super, Peter Downie, David D Eisenstat, Gabrielle Haeusler, Brendan McMullan and 20 more

Open access · bronzeAbstract readConsensus Statement
In one paragraph

Article in The Medical journal of Australia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors at 16 institutions in 2 countries.

Eliska FurlongPerth Children's Hospital, Perth, WA.
Rishi S KotechaPerth Children's Hospital, Perth, WA.ORCID 0000-0003-1836-4075
Rachel ConyersMurdoch Children's Research Institute, Melbourne, VIC.
Tracey A O'BrienKids Cancer Centre, Sydney Children's Hospital, Sydney, NSW.
Jordan R HansfordMurdoch Children's Research Institute, Melbourne, VIC.
Leanne SuperChildren's Cancer Centre, Royal Children's Hospital, Melbourne, VIC.
Peter DownieMonash University, Melbourne, VIC.
David D EisenstatMurdoch Children's Research Institute, Melbourne, VIC.
Gabrielle HaeuslerMurdoch Children's Research Institute, Melbourne, VIC.
Brendan McMullanUniversity of New South Wales, Sydney, NSW.
Marianne B PhillipsPerth Children's Hospital, Perth, WA.
Bhavna PadhyeCancer Centre for Children, The Children's Hospital at Westmead, Sydney, NSW.
Luciano Dalla-PozzaCancer Centre for Children, The Children's Hospital at Westmead, Sydney, NSW.
Frank AlvaroJohn Hunter Children's Hospital, Newcastle, NSW.
Christopher J FraserQueensland Children's Hospital, Brisbane, QLD.
Wayne NichollsQueensland Children's Hospital, Brisbane, QLD.
Julia E ClarkQueensland Children's Hospital, Brisbane, QLD.
Matthew O'ConnorMichael Rice Centre for Haematology and Oncology, Women's and Children's Hospital, Adelaide, SA.ORCID 0000-0001-8965-1245
Benjamin R SaxonMichael Rice Centre for Haematology and Oncology, Women's and Children's Hospital, Adelaide, SA.
Heather TappMichael Rice Centre for Haematology and Oncology, Women's and Children's Hospital, Adelaide, SA.
John HeathChildren's and Adolescent/Young Adult Cancer Centre, Royal Hobart Hospital, Hobart, TAS.
Sarah E HunterBlood and Cancer Centre, Starship Children's Hospital, Auckland, NZ.
Karen TsuiBlood and Cancer Centre, Starship Children's Hospital, Auckland, NZ.
Mark WinstanleyBlood and Cancer Centre, Starship Children's Hospital, Auckland, NZ.
Amanda LyverChildren's Haematology Oncology Centre, Christchurch Hospital, Christchurch, NZ.
Emma J BestStarship Children's Hospital, Auckland, NZ.
Ushma WadiaPerth Children's Hospital, Perth, WA.
Daniel YeohPerth Children's Hospital, Perth, WA.
Christopher C BlythPerth Children's Hospital, Perth, WA.ORCID 0000-0003-2017-0683
Nicholas G GottardoPerth Children's Hospital, Perth, WA.
Royal Children's Hospital · AUPrincess Margaret Hospital for Children · AUStarship Children's Health · NZThe Kids Research Institute Australia · AUWomen's and Children's Hospital · AUChildren's Hospital at Westmead · AUThe University of Queensland · AUUNSW Sydney · AUChildren's Health Queensland Hospital and Health Service · AUChristchurch Hospital · NZHudson Institute of Medical Research · AUJohn Hunter Children's Hospital · AUMurdoch Children's Research Institute · AURoyal Hobart Hospital · AUThe University of Western Australia · AUUniversity of Auckland · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe Australian Technical Advisory Group on Immunisation and New Zealand Ministry of Health recommend all children aged ≥ 5 years receive either of the two mRNA COVID-19 vaccines: Comirnaty (Pfizer), available in both Australia and New Zealand, or Spikevax (Moderna), available in Australia only. Both vaccines are efficacious and safe in the general population, including children. Children and adolescents undergoing treatment for cancer and immunosuppressive therapy for non-malignant haematological conditions are particularly vulnerable, with an increased risk of severe or fatal COVID-19. There remains a paucity of data regarding the immune response to COVID-19 vaccines in immunosuppressed paediatric populations, with data suggestive of reduced immunogenicity of the vaccine in immunocompromised adults. RECOMMENDATIONS: Considering the safety profile of mRNA COVID-19 vaccines and the increased risk of severe COVID-19 in immunocompromised children and adolescents, COVID-19 vaccination is strongly recommended for this at-risk population. We provide a number of recommendations regarding COVID-19 vaccination in this population where immunosuppressive, chemotherapeutic and/or targeted biological agents are used. These include the timing of vaccination in patients undergoing active treatment, management of specific situations where vaccination is contraindicated or recommended under special precautions, and additional vaccination recommendations for severely immunocompromised patients. Finally, we stress the importance of upcoming clinical trials to identify the safest and most efficacious vaccination regimen for this population. CHANGES IN MANAGEMENT AS A RESULT OF THIS STATEMENT: This consensus statement provides recommendations for COVID-19 vaccination in children and adolescents aged ≥ 5 years with cancer and immunocompromising non-malignant haematological conditions, based on evidence, national and international guidelines and expert opinion. ENDORSED BY: The Australian and New Zealand Children's Haematology/Oncology Group.

Indexed as

COVID-19HematologyNeoplasmsAdolescentAustraliaChildChild, PreschoolCOVID-19 VaccinesHumansNew ZealandVaccinationCOVID-19 VaccinesImmune System DiseasesInfectious diseasesNeoplasmsPediatric medicine

Identifiers

PMID35201615
PMCPMC9115069
OpenAlexW4213445446

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.