ArticleArchives of pharmacal research2022
New phenalenone derivatives from the Hawaiian volcanic soil-associated fungus Penicillium herquei FT729 and their inhibitory effects on indoleamine 2,3-dioxygenase 1 (IDO1).
Article in Archives of pharmacal research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
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- Genomic characterization and identification of candidate genes for putative podophyllotoxin biosynthesis pathway in Penicillium herquei HGN12.1C.Microbial biotechnology · 2024Article
- Proanthocyanidins and Phenolic Compounds from the Twigs ofNutrients · 2024Article
- Determination of the Absolute Configuration of Secondary Alcohols in a Compound Mixture via the Application of Competing Enantioselective Acylation Coupled with LC/MS Analysis.Pharmaceutics · 2024Article
- New autophagy-modulating lanostane-type triterpenoids from a hallucinogenic poisonous mushroom Gymnopilus orientispectabilis.Archives of pharmacal research · 2024Article
- Chaenomelin, a New Phenolic Glycoside, and Anti-Plants (Basel, Switzerland) · 2024Article
- 3‴-Plants (Basel, Switzerland) · 2023Article
- Global Natural Products Social (GNPS)-Based Molecular-Networking-Guided Isolation of Phenolic Compounds fromPlants (Basel, Switzerland) · 2023Article
- Antiviral Effects of Secondary Metabolites fromPlants (Basel, Switzerland) · 2023Article
- 6-Pentyl-α-Pyrone fromAntioxidants (Basel, Switzerland) · 2023Article
- Phytochemical Investigation ofPharmaceuticals (Basel, Switzerland) · 2023Article
- Anti-osteoporosis effects of triterpenoids from the fruit of sea buckthorn (Hippophae rhamnoides) through the promotion of osteoblast differentiation in mesenchymal stem cells, C3H10T1/2.Archives of pharmacal research · 2023Article
- Laricitrin 3-Rutinoside fromAntioxidants (Basel, Switzerland) · 2023Article
- Article
- Methoxyflavones from Black Ginger (Plants (Basel, Switzerland) · 2023Article
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Authors and funding
10 authors.
Funding
Abstract
Phenalenone derivatives sourced from fungi are polyketides that have attracted significant interest because of their diverse chemical structures and potential bioactivities. As part of our ongoing quest to discover novel natural products with biological properties from diverse natural resources, three unreported phenalenone derivatives (1-3), named ent-12-methoxyisoherqueinone (1), (-)-scleroamide (2), and (+)-scleroamide (3), together with four known phenalenone derivatives, ent-atrovenetinone (4), isoherqueinone (5), herqueinone (6), and ent-peniciherquinone (7) were isolated from the Hawaiian soil fungus Penicillium herquei FT729, collected on the Big Island, Hawaii. Compounds 2 and 3 were enantiomers, which were separated using a chiral-phase HPLC column, which provided optically pure compounds 2 and 3. The structures of the novel compounds were established by extensive spectroscopic analyses, including 1D and 2D NMR and high-resolution ESIMS. Their absolute configurations were determined using quantum chemical electronic circular dichroism (ECD) calculations. The inhibitory activity of the isolated compounds (1-7) against indoleamine 2,3-dioxygenase 1 (IDO1) was assessed. Compounds 1, 5-7 inhibited IDO1, with IC
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