Evidence map›Paper›PMID 35201440›Full record

ReviewDiscover oncology2021

Recent advances in cancer immunotherapy.

Qiang Sun, Gerry Melino, Ivano Amelio, Jingting Jiang, Ying Wang, Yufang Shi

Abstract readReview
In one paragraph

Review in Discover oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qiang SunLaboratory of Cell Engineering, Institute of Biotechnology, Beijing, China.ORCID http://orcid.org/0000-0001-8094-2214
Gerry MelinoDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.ORCID http://orcid.org/0000-0001-9428-5972
Ivano AmelioDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy.ORCID http://orcid.org/0000-0003-0739-325X
Jingting JiangThe Third Affiliated Hospital of Soochow University and State Key Laboratory of Radiation Medicine and Protection, Institutes for Translational Medicine, Soochow University, 199 Renai Road, Suzhou, 215123, Jiangsu, China.ORCID http://orcid.org/0000-0002-3128-9762
Ying WangCAS Key Laboratory of Tissue Microenvironment and Tumor, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China.ORCID http://orcid.org/0000-0002-2571-9367
Yufang ShiDepartment of Experimental Medicine, TOR, University of Rome Tor Vergata, 00133, Rome, Italy. shiyufang2@gmail.com.ORCID http://orcid.org/0000-0001-8964-319X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer immunotherapy represents a major advance in the cure of cancer following the dramatic advancements in the development and refinement of chemotherapies and radiotherapies. In the recent decades, together with the development of early diagnostic techniques, immunotherapy has significantly contributed to improving the survival of cancer patients. The immune-checkpoint blockade agents have been proven effective in a significant fraction of standard therapy refractory patients. Importantly, recent advances are providing alternative immunotherapeutic tools that could help overcome their limitations. In this mini review, we provide an overview on the main steps of the discovery of classic immune-checkpoint blockade agents and summarise the most recent development of novel immunotherapeutic strategies, such as tumour antigens, bispecific antibodies and TCR-engineered T cells.

Indexed as

Cancer immunotherapyCancer survivalImmune check point blockadeKRasp53T cell receptor

Identifiers

PMID35201440
PMCPMC8777500

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.