Evidence map›Paper›PMID 35201404›Full record

Trial reportGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2022

Effect of obstructive sleep apnoea on retinal microvascular function: a randomised controlled trial.

Chris D Turnbull, James A Stockley, Shyam Madathil, Syed S A Huq, Brendan G Cooper, Asad Ali, Simon Wharton, John R Stradling, Rebekka Heitmar

Open access · hybridAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Chris D TurnbullNuffield Department of Medicine, University of Oxford, Oxford, UK. christopher.turnbull@ouh.nhs.uk.ORCID http://orcid.org/0000-0001-8942-5424
James A StockleyLung Function & Sleep, Queen Elizabeth Hospital, University Hospitals Birmingham NHSFT, Birmingham, B15 2GW, West Midlands, UK.
Shyam MadathilLung Function & Sleep, Queen Elizabeth Hospital, University Hospitals Birmingham NHSFT, Birmingham, B15 2GW, West Midlands, UK.
Syed S A HuqLung Function & Sleep, Queen Elizabeth Hospital, University Hospitals Birmingham NHSFT, Birmingham, B15 2GW, West Midlands, UK.
Brendan G CooperLung Function & Sleep, Queen Elizabeth Hospital, University Hospitals Birmingham NHSFT, Birmingham, B15 2GW, West Midlands, UK.
Asad AliDepartment of Sleep and Respiratory Medicine, University Hospital Coventry and Warwickshire, Coventry, CV2 2DX, Warwickshire, UK.
Simon WhartonSleep Department, Heartlands Hospital, University Hospitals Birmingham NHSFT, Birmingham, B15 2GW, West Midlands, UK.
John R StradlingNIHR Biomedical Research Centre, University of Oxford, Oxford, UK.
Rebekka HeitmarSchool of Applied Sciences, Department of Optometry and Vision Sciences, University of Huddersfield, Huddersfield, UK.
Queen Elizabeth Hospital Birmingham · GBUniversity of Oxford · GBHeartlands Hospital · GBUniversity Hospital Coventry · GBUniversity of Huddersfield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRetinal microvascular endothelial dysfunction is thought to be of importance in the development of ocular vascular diseases. Obstructive sleep apnoea (OSA) causes macrovascular endothelial dysfunction, but the effect of OSA on retinal microvascular endothelial function is not known. We aimed to determine the effect of OSA on retinal microvascular function.

methodsWe conducted a multi-centre, double-blind, randomised, parallel, controlled trial in patients with known moderate-to-severe OSA, established on continuous positive airway pressure (CPAP). Participants were randomised to 14 nights of either continued CPAP or sham CPAP to generate a return of OSA. Retinal vascular responses to flickering light were measured using dynamic vessel analysis both at baseline and after 14 nights of intervention. The primary outcome was the change from baseline to follow-up in the area under the curve of the arteriolar response to flickering light, sham CPAP versus continued CPAP.

resultsNineteen patients were randomised to sham CPAP, and 18 patients were randomised to continued CPAP. There was no significant effect of CPAP withdrawal and return of OSA on retinal responses, with a change in the area under the curve of the arteriole response to flickering light of + 3.8 arbitrary units (95% CI - 10.6 to + 18.2, p = 0.59), sham CPAP versus continued CPAP.

conclusionsCPAP withdrawal and a return of OSA had no significant effect on retinal microvascular responses. This contrasts with the effect of CPAP withdrawal on macrovascular endothelial function and suggests that OSA has different effects on macrovascular and microvascular endothelial function. ISRCTN 78082983, 23/10/2014, Prospectively registered.

Indexed as

Sleep Apnea, ObstructiveContinuous Positive Airway PressureDouble-Blind MethodHumansAutoregulationEndothelial functionObstructive sleep apnoeaOcular vascular diseaseRetinal vascular reactivity

Identifiers

PMID35201404
PMCPMC8866916
OpenAlexW4214487432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.