ArticleTranslational vision science & technology2022
Choriocapillaris Changes in Myopic Macular Degeneration.
Article in Translational vision science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 0 citations in OpenAlex.
- Axial length as a predictor of myopic macular degeneration: a meta-analysis and clinical study.Eye (London, England) · 2025Pooled it
- Two-year changes of macular choroidal thickness in response to 0.01% atropine eye drops: Results from the myopia outcome study of atropine in children (MOSAIC) clinical trial.Acta ophthalmologica · 2025Trial
- A bibliometric and visualized analysis of choriocapillaris from 2013 to 2023.International journal of ophthalmology · 2026Article
- Strong association between decreased stroma in Sattler's layer and high myopia.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Artificial intelligence-assisted quantification of fundus tessellation in early-onset high myopia.Frontiers in medicine · 2025Article
- Curvature of Posterior Pole in Eyes with Retinitis Pigmentosa.Journal of clinical medicine · 2024Article
- In-vivo characterization of scleral rigidity in myopic eyes using fundus-pulsation optical coherence elastography.Biomedical optics express · 2024Article
- Using choroidal thickness to detect myopic macular degeneration.International journal of ophthalmology · 2024Article
- Fundus Tessellated Density Assessed by Deep Learning in Primary School Children.Translational vision science & technology · 2023Article
- IMI 2023 Digest.Investigative ophthalmology & visual science · 2023Article
- Evidence of vascular involvement in myopia: a review.Frontiers in medicine · 2023Review
- Assessment of Choroidal Vasculature and Innate Immune Cells in the Eyes of Albino and Pigmented Mice.Cells · 2022Article
- Compartmental analysis of three-dimensional choroidal vascularity and thickness of myopic eyes in young adults using SS-OCTA.Frontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeMyopic macular degeneration (MMD) can cause irreversible vision loss. Thinner choroid is associated with increased MMD severity. This cross-sectional study analyzed choriocapillaris (CC) alterations in MMD.
methodsAxial length (AL), best-corrected visual acuity (BCVA), fundus photography, and swept-source optical coherence tomography angiography (SS-OCTA) were assessed in controls and high myopes (spherical equivalent ≤ -6 diopters). Myopic patients with grade 2 MMD (macular diffuse chorioretinal atrophy [MDCA]), high axial myopia (AL ≥ 26.5 mm), and BCVA ≥ 20/40 were compared with controls without MMD. CC mean thickness was measured from 3 × 3-mm SS-OCTA scans by identifying CC peaks in A-scan intensity profiles. CC flow deficit percent (CC FD%) was quantified using a fuzzy C-mean local thresholding method on en face OCTA images. Multivariate regressions compared CC thickness and CC FD% between myopic patients and controls, correcting for age and other confounders.
resultsSixteen eyes with MDCA (AL, 26.96-33.93 mm; ages, 40-78 years) were compared with 51 control eyes (AL, 21.65-25.84 mm; ages, 19-88 years). CC thickness in patients with MDCA was 66% lower than that in controls (5.23 ± 0.68 µm [mean ± SD] vs. 15.46 ± 1.82 µm; P < 0.001). CC FD% in patients with MDCA was 237% greater than in controls (26.5 ± 4.3 vs. 11.2 ± 4.6; P < 0.001).
conclusionsPatients with MDCA with good visual acuity had thinner CC and increased CC FD%, or reduced CC flow, compared with controls. Patients with grade 2 MMD and good visual acuity demonstrated significant choriocapillaris alterations, suggesting that choriocapillaris perfusion defects contribute to the pathogenesis of MMD. TRANSLATIONAL RELEVANCE: Given the potential vascular etiology for MMD, current research about revascularization of ischemic retina likely has implications for the treatment of MMD.
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