Evidence map›Paper›PMID 35200636›Full record

ArticleMarine drugs2022

Efficient Isolation of Mycosporine-Like Amino Acids from Marine Red Algae by Fast Centrifugal Partition Chromatography.

Michael Zwerger, Stefan Schwaiger, Markus Ganzera

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael ZwergerDepartment of Pharmacognosy, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria.ORCID 0000-0002-0245-6146
Stefan SchwaigerDepartment of Pharmacognosy, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria.ORCID 0000-0002-3731-7349
Markus GanzeraDepartment of Pharmacognosy, Institute of Pharmacy, University of Innsbruck, A-6020 Innsbruck, Austria.ORCID 0000-0002-7407-9060
Universität Innsbruck · AT

Funding

Austrian Science Fund FWF P 29671FWF Austrian Science Fund P29671
6 · The paper itself

Abstract

Marine rhodophyta are known to synthesize specific secondary metabolites, mycosporine-like amino acids (MAAs), to protect themselves from harmful UV-radiation. Shinorine and porphyra-334 are among the most abundant representatives of this compound class. In the present work, a novel approach for their isolation is described. As a first step, a fast centrifugal partition chromatography method, with an aqueous two-phase system comprising water, ethanol, ammonium sulfate and methanol in ascending mode, was developed to isolate the two MAAs from crude aqueous-methanolic extracts of three algal species within 90 min. The compounds could be isolated when just one of them was present in a sample or also both at the same time. By employing solid phase extraction as a second purification step, the individual MAAs were obtained in high purity and good quantity within a much shorter time frame than the established purification protocols, e.g., semi-preparative HPLC. For example, from 4 g

Indexed as

Amino AcidsChromatography, High Pressure LiquidChromatography, LiquidChromatography, Thin LayerMagnetic Resonance SpectroscopyRhodophytaSecondary MetabolismSolid Phase ExtractionAmino AcidsFCPCisolationMAAmycosporine-like amino acidsporphyra-334shinorine

Identifiers

PMID35200636
PMCPMC8879178
OpenAlexW4210657158

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.