ReviewCurrent oncology (Toronto, Ont.)2022
Minimally Invasive Surgery for Cervical Cancer in Light of the LACC Trial: What Have We Learned?
Review in Current oncology (Toronto, Ont.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- MILACC study: could undetected lymph node micrometastases have impacted recurrence rate in the LACC trial?International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023Trial
- Robotic Versus Open Radical Hysterectomy in Early-Stage Cervical Cancer: A Comparative Cohort Study.Journal of clinical medicine · 2026Article
- Endometrial Cancer Recurrence Risk Following Robotic Hysterectomy.Current oncology (Toronto, Ont.) · 2026Article
- The Application of Tumor-Free Technique in Robotic Single-Site Radical Hysterectomy for Early Stage Cervical Cancer.Annals of surgical oncology · 2026Article
- Impact of laparoscopic versus open surgery on 5-year survival in patients with stage IA2-IB1 cervical cancer: a retrospective cohort study.American journal of cancer research · 2026Article
- Are Uterine Manipulators Harmful in Minimally Invasive Endometrial Cancer Surgery? A Retrospective Cohort Study.Cancers · 2025Article
- Laparoscopy in the Surgical Management of Gynecological Cancer: A Comprehensive Update.Journal of clinical medicine · 2025Review
- Vaginal Tumor Cell Exfoliation in Cervical and Endometrial Cancer: A Comparative Washing Cytology Study with Implications for Minimally Invasive Surgery.Journal of clinical medicine · 2025Article
- Robotic radical trachelectomy in early stage cervical cancer.Journal of robotic surgery · 2025Review
- The clinical practice and outcomes of minimally invasive surgery in primary malignant melanoma of the vagina and cervix patients: a retrospective cohort study.Orphanet journal of rare diseases · 2025Article
- A Minimally Invasive Treatment Approach for Early-Stage Uterine Cervical Cancer: The Impact of the LACC Trial and a Literature Review.Medicina (Kaunas, Lithuania) · 2025Review
- Minimally invasive surgery in gynecologic oncology: a narrative review of controversies and clinical implications.Gynecology and pelvic medicine · 2025Review
- Article
- Trends in Early-Stage Cervical Cancer Management in the US: A National Cancer Database Analysis.Current oncology (Toronto, Ont.) · 2024Article
- Surgery Advances in Gynecologic Tumors: The Evolution and Outcomes of Robotic Surgery for Gynecologic Cancers in a Tertiary Center.Current oncology (Toronto, Ont.) · 2024Review
- Current analysis of the survival implications for minimally invasive surgery in the treatment of early-stage cervix cancer.Journal of robotic surgery · 2024Review
- Type and approach of hysterectomy and oncological survival of women with stage II cancer of endometrium: a large retrospective cohort study.Frontiers in oncology · 2024Article
- Development and Validation of Radiomics-Based Models for Predicting the Parametrial Invasion in Stage IB1 to IIA2 Cervical Cancer.International journal of general medicine · 2024Article
- Article
- Comparison of the survival outcomes of laparoscopic, abdominal and gasless laparoscopic radical hysterectomy for early-stage cervical cancer: trial protocol of a multicenter randomized controlled trial (LAGCC trial).Frontiers in oncology · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical cancer is the most common gynecologic malignancy and the fourth most common cancer in women worldwide. Over the last two decades, minimally invasive surgery (MIS) emerged as the mainstay in the surgical management of cervical cancer, bringing advantages such as lower operative morbidity and shorter hospital stay compared to open surgery while maintaining comparable oncologic outcomes in numerous retrospective studies. However, in 2018, a prospective phase III randomized controlled trial, "Laparoscopic Approach to Carcinoma of the Cervix (LACC)", unexpectedly reported that MIS was associated with a statistically significant poorer overall survival and disease-free survival compared to open surgery in patients with early-stage cervical cancer. Various hypotheses have been raised by the authors to try to explain these results, but the LACC trial was not powered to answer those questions. In this study, through an exhaustive literature review, we wish to explore some of the potential causes that may explain the poorer oncologic outcomes associated with MIS, including the type of MIS surgery, the size of the lesion, the impact of CO
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.