Evidence map›Paper›PMID 35200488›Full record

ArticleGels (Basel, Switzerland)2022

Biocompatible Chitosan-Based Hydrogels for Bioabsorbable Wound Dressings.

Ramona Lungu, Maria-Alexandra Paun, Dragos Peptanariu, Daniela Ailincai, Luminita Marin, Mihai-Virgil Nichita, Vladimir-Alexandru Paun, Viorel-Puiu Paun

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 42 citations in OpenAlex.

  1. Black Sea-Derived Biomaterials for Wound-Healing Applications.International journal of molecular sciences · 2026
    Article
  2. Review
  3. Article
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  5. Article
  6. Article
  7. Pharmaceutics · 2024
    Article
  8. Article
  9. Article
  10. Bioengineering (Basel, Switzerland) · 2024
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  11. Review
  12. Article
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  14. Article
  15. Article
  16. Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Ramona Lungu"Petru Poni" Institute of Macromolecular Chemistry, Gr. Ghica Voda Alley, 41A, 700487 Iasi, Romania.
Maria-Alexandra PaunSchool of Engineering, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland.ORCID 0000-0003-2088-7457
Dragos Peptanariu"Petru Poni" Institute of Macromolecular Chemistry, Gr. Ghica Voda Alley, 41A, 700487 Iasi, Romania.
Daniela Ailincai"Petru Poni" Institute of Macromolecular Chemistry, Gr. Ghica Voda Alley, 41A, 700487 Iasi, Romania.
Luminita Marin"Petru Poni" Institute of Macromolecular Chemistry, Gr. Ghica Voda Alley, 41A, 700487 Iasi, Romania.ORCID 0000-0003-3987-4912
Mihai-Virgil NichitaDoctoral School, Faculty of Applied Sciences, University Politehnica of Bucharest, 060042 Bucharest, Romania.
Vladimir-Alexandru PaunFive Rescue Research Laboratory, 75004 Paris, France.
Viorel-Puiu PaunPhysics Department, Faculty of Applied Sciences, University Politehnica of Bucharest, 060042 Bucharest, Romania.
Academia Oamenilor de Știință din România · RORomanian Academy · ROÉcole Polytechnique Fédérale de Lausanne · CHUniversitatea Națională de Știință și Tehnologie Politehnica București · RO

Funding

Ministerul Cercetării și Inovării 538PED/2020 within PNCDI III.
6 · The paper itself

Abstract

Supramolecular hydrogels based on chitosan and monoaldehydes are biomaterials with high potential for a multitude of bioapplications. This is due to the proper choice of the monoaldehyde that can tune the hydrogel properties for specific practices. In this conceptual framework, the present paper deals with the investigation of a hydrogel as bioabsorbable wound dressing. To this aim, chitosan was cross-linked with 2-formylphenylboronic acid to yield a hydrogel with antimicrobial activity. FTIR, NMR, and POM procedures have characterized the hydrogel from a structural and supramolecular point of view. At the same time, its biocompatibility and antimicrobial properties were also determined in vitro. Furthermore, in order to assess the bioabsorbable character, its biodegradation was investigated in vitro in the presence of lysosome in media of different pH, mimicking the wound exudate at different stages of healing. The biodegradation was monitored by gravimetrical measurements, SEM microscopy and fractal analyses of the images. The fractal dimension values and the lacunarity of SEM pictures were accurately calculated. All these successful investigations led to the conclusion that the tested materials are at the expected high standards.

Indexed as

antimicrobial activitybiocompatibilitybiodegradationfractal analysishydrogelSEM image

Identifiers

PMID35200488
PMCPMC8871869
OpenAlexW4210967054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.