Evidence map›Paper›PMID 35200476›Full record

ArticleGels (Basel, Switzerland)2022

Scaffolds for Cultured Meat on the Basis of Polysaccharide Hydrogels Enriched with Plant-Based Proteins.

Jannis O Wollschlaeger, Robin Maatz, Franziska B Albrecht, Annemarie Klatt, Simon Heine, Andreas Blaeser, Petra J Kluger

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
9.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 68 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Edible Scaffolds for Cultivated Meat Production.Advances in biochemical engineering/biotechnology · 2026
    Review
  6. Article
  7. Starch-Based Scaffolds for Cultivated Meat Production: Challenges and Perspectives.Comprehensive reviews in food science and food safety · 2025
    Review
  8. Article
  9. Scaffolds Bioink for Three-Dimensional (3D) Bioprinting.Food science of animal resources · 2025
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jannis O WollschlaegerReutlingen Research Institute, Reutlingen University, 72762 Reutlingen, Germany.
Robin MaatzInstitute for BioMedical Printing Technology, Technical University of Darmstadt, 64289 Darmstadt, Germany.
Franziska B AlbrechtReutlingen Research Institute, Reutlingen University, 72762 Reutlingen, Germany.
Annemarie KlattReutlingen Research Institute, Reutlingen University, 72762 Reutlingen, Germany.
Simon HeineReutlingen Research Institute, Reutlingen University, 72762 Reutlingen, Germany.ORCID 0000-0002-8006-3348
Andreas BlaeserInstitute for BioMedical Printing Technology, Technical University of Darmstadt, 64289 Darmstadt, Germany.
Petra J KlugerSchool of Applied Chemistry, Reutlingen University, 72762 Reutlingen, Germany.ORCID 0000-0001-6784-7378
Reutlingen University · DETechnische Universität Darmstadt · DE

Funding

Avina Foundation (Switzerland) no number availableNew Harvest no number available
6 · The paper itself

Abstract

The world population is growing and alternative ways of satisfying the increasing demand for meat are being explored, such as using animal cells for the fabrication of cultured meat. Edible biomaterials are required as supporting structures. Hence, we chose agarose, gellan and a xanthan-locust bean gum blend (XLB) as support materials with pea and soy protein additives and analyzed them regarding material properties and biocompatibility. We successfully built stable hydrogels containing up to 1% pea or soy protein. Higher amounts of protein resulted in poor handling properties and unstable gels. The gelation temperature range for agarose and gellan blends is between 23-30 °C, but for XLB blends it is above 55 °C. A change in viscosity and a decrease in the swelling behavior was observed in the polysaccharide-protein gels compared to the pure polysaccharide gels. None of the leachates of the investigated materials had cytotoxic effects on the myoblast cell line C2C12. All polysaccharide-protein blends evaluated turned out as potential candidates for cultured meat. For cell-laden gels, the gellan blends were the most suitable in terms of processing and uniform distribution of cells, followed by agarose blends, whereas no stable cell-laden gels could be formed with XLB blends.

Indexed as

agarosebiofabricationC2C12 immortalized myoblastscell-laden hydrogelsgellanxanthan-locust bean gum blend

Identifiers

PMID35200476
PMCPMC8871916
OpenAlexW4210352890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.