Evidence map›Paper›PMID 35200447›Full record

ArticleGels (Basel, Switzerland)2022

Analysis of Three-Dimensional Cell Migration in Dopamine-Modified Poly(aspartic acid)-Based Hydrogels.

David Juriga, Eszter Eva Kalman, Krisztina Toth, Dora Barczikai, David Szöllősi, Anna Földes, Gabor Varga, Miklos Zrinyi, Angela Jedlovszky-Hajdu, Krisztina S Nagy

Open access · goldAbstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. New Insights in Hydrogels for Periodontal Regeneration.Journal of functional biomaterials · 2023
    Review
  5. Article
  6. Editorial: Biomaterial applications in soft tissue engineering and replacement.Frontiers in bioengineering and biotechnology · 2023
    Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

David JurigaDepartment of Biophysics and Radiation Biology, Semmelweis University, H-1089 Budapest, Hungary.ORCID 0000-0003-2655-5584
Eszter Eva KalmanDepartment of Molecular Biology, Semmelweis University, H-1083 Budapest, Hungary.
Krisztina TothDepartment of Biophysics and Radiation Biology, Semmelweis University, H-1089 Budapest, Hungary.
Dora BarczikaiDepartment of Biophysics and Radiation Biology, Semmelweis University, H-1089 Budapest, Hungary.
David SzöllősiDepartment of Biophysics and Radiation Biology, Semmelweis University, H-1089 Budapest, Hungary.ORCID 0000-0002-3363-3862
Anna FöldesDepartment of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary.
Gabor VargaDepartment of Oral Biology, Semmelweis University, H-1089 Budapest, Hungary.ORCID 0000-0002-5506-8198
Miklos ZrinyiDepartment of Biophysics and Radiation Biology, Semmelweis University, H-1089 Budapest, Hungary.
Angela Jedlovszky-HajduDepartment of Biophysics and Radiation Biology, Semmelweis University, H-1089 Budapest, Hungary.ORCID 0000-0003-2720-783X
Krisztina S NagyDepartment of Biophysics and Radiation Biology, Semmelweis University, H-1089 Budapest, Hungary.ORCID 0000-0002-4942-2947
Semmelweis University · HU

Funding

EFOP EFOP-3.6.2-16-2017-00006National Research, Development and Innovation Office 137749
6 · The paper itself

Abstract

Several types of promising cell-based therapies for tissue regeneration have been developing worldwide. However, for successful therapeutical application of cells in this field, appropriate scaffolds are also required. Recently, the research for suitable scaffolds has been focusing on polymer hydrogels due to their similarity to the extracellular matrix. The main limitation regarding amino acid-based hydrogels is their difficult and expensive preparation, which can be avoided by using poly(aspartamide) (PASP)-based hydrogels. PASP-based materials can be chemically modified with various bioactive molecules for the final application purpose. In this study, dopamine containing PASP-based scaffolds is investigated, since dopamine influences several cell biological processes, such as adhesion, migration, proliferation, and differentiation, according to the literature. Periodontal ligament cells (PDLCs) of neuroectodermal origin and SH-SY5Y neuroblastoma cell line were used for the in vitro experiments. The chemical structure of the polymers and hydrogels was proved by

Indexed as

dopaminehydrogel scaffoldpoly(aspartic acid) hydrogelSH-SY5Ythree-dimensional cell migration

Identifiers

PMID35200447
PMCPMC8870902
OpenAlexW4206768816

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.