Evidence map›Paper›PMID 35200386›Full record

ArticleBiosensors2022

Academic User View: Organ-on-a-Chip Technology.

Mathias Busek, Aleksandra Aizenshtadt, Mikel Amirola-Martinez, Ludivine Delon, Stefan Krauss

Abstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Biosensor applications in organ-on-a-chip platforms and disease modeling.Frontiers in bioengineering and biotechnology · 2026
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  15. Boosting the Clinical Translation of Organ-on-a-Chip Technology.Bioengineering (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mathias BusekHybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
Aleksandra AizenshtadtHybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.ORCID 0000-0003-1642-9250
Mikel Amirola-MartinezHybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.
Ludivine DelonDepartment of Immunology and Transfusion Medicine, Oslo University Hospital, 0424 Oslo, Norway.
Stefan KraussHybrid Technology Hub-Centre of Excellence, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway.

Funding

European Union Marie Skłodowska-Curie Actions Grant agreement No 801133The Research Council of Norway Centers of Excellence scheme, project number 262613
6 · The paper itself

Abstract

Organ-on-a-Chip (OoC) systems bring together cell biology, engineering, and material science for creating systems that recapitulate the in vivo microenvironment of tissues and organs. The versatility of OoC systems enables in vitro models for studying physiological processes, drug development, and testing in both academia and industry. This paper evaluates current platforms from the academic end-user perspective, elaborating on usability, complexity, and robustness. We surveyed 187 peers in 35 countries and grouped the responses according to preliminary knowledge and the source of the OoC systems that are used. The survey clearly shows that current commercial OoC platforms provide a substantial level of robustness and usability-which is also indicated by an increasing adaptation of the pharmaceutical industry-but a lack of complexity can challenge their use as a predictive platform. Self-made systems, on the other hand, are less robust and standardized but provide the opportunity to develop customized and more complex models, which are often needed for human disease modeling. This perspective serves as a guide for researchers in the OoC field and encourages the development of next-generation OoCs.

Indexed as

Drug DevelopmentLab-On-A-Chip DevicesHumansTechnologydisease modelsdrug testinglimitationsmicrophysiological systems (MPS)organ-on-a-chip (OoC)surveyusability

Identifiers

PMID35200386
PMCPMC8869899

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.