Evidence map›Paper›PMID 35200380›Full record

ArticleBiosensors2022

Enhanced Blood Plasma Extraction Utilising Viscoelastic Effects in a Serpentine Microchannel.

Yuchen Dai, Haotian Cha, Michael J Simmonds, Hedieh Fallahi, Hongjie An, Hang T Ta, Nam-Trung Nguyen, Jun Zhang, Antony P McNamee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yuchen DaiQueensland Micro-Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia.ORCID 0000-0002-8960-4040
Haotian ChaQueensland Micro-Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia.
Michael J SimmondsBiorheology Research Laboratory, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia.
Hedieh FallahiQueensland Micro-Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia.ORCID 0000-0002-6016-4782
Hongjie AnQueensland Micro-Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia.
Hang T TaSchool of Environment and Science, Griffith University, Nathan, QLD 4111, Australia.ORCID 0000-0003-1188-0472
Nam-Trung NguyenQueensland Micro-Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia.ORCID 0000-0003-3626-5361
Jun ZhangQueensland Micro-Nanotechnology Centre, Griffith University, Nathan, QLD 4111, Australia.ORCID 0000-0003-1113-6264
Antony P McNameeBiorheology Research Laboratory, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia.

Funding

Australian Research Council DP180100055;DE210100692; FT180100361Griffith University MHIQ Collaborative Interdisciplinary Grants 2021
6 · The paper itself

Abstract

Plasma extraction from blood is essential for diagnosis of many diseases. The critical process of plasma extraction requires removal of blood cells from whole blood. Fluid viscoelasticity promotes cell migration towards the central axis of flow due to differences in normal stress and physical properties of cells. We investigated the effects of altering fluid viscoelasticity on blood plasma extraction in a serpentine microchannel. Poly (ethylene oxide) (PEO) was dissolved into blood to increase its viscoelasticity. The influences of PEO concentration, blood dilution, and flow rate on the performance of cell focusing were examined. We found that focusing performance can be significantly enhanced by adding PEO into blood. The optimal PEO concentration ranged from 100 to 200 ppm with respect to effective blood cell focusing. An optimal flow rate from 1 to 15 µL/min was determined, at least for our experimental setup. Given less than 1% haemolysis was detected at the outlets in all experimental combinations, the proposed microfluidic methodology appears suitable for applications sensitive to haemocompatibility.

Indexed as

MicrofluidicsPlasmaPolyethylene GlycolsSecologanin Tryptamine AlkaloidsViscosityPolyethylene GlycolsSecologanin Tryptamine Alkaloidsserpentine (alkaloid)blood plasma separationmicrofluidicsparticle migrationviscoelasticity

Identifiers

PMID35200380
PMCPMC8869685

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.