Evidence map›Paper›PMID 35200374›Full record

ArticleBiosensors2022

Decoding Vagus-Nerve Activity with Carbon Nanotube Sensors in Freely Moving Rodents.

Joseph T Marmerstein, Grant A McCallum, Dominique M Durand

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Dysregulated neural coding in the vagus nerve during long sepsis.Brain, behavior, & immunity - health · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Joseph T MarmersteinNeural Engineering Center, Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-4093-9616
Grant A McCallumNeural Engineering Center, Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0001-5009-914X
Dominique M DurandNeural Engineering Center, Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.ORCID 0000-0002-8355-6324
Case Western Reserve University · US

Funding

SLOWLY PENETRATING INTERFASCICULAR NERVE ELECTRODER01NS032845 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI DURAND, DOMINIQUE M · 1994 to 2022
$8.3M
NIH HHS 5R01NS032845-22NINDS NIH HHS R01 NS032845
6 · The paper itself

Abstract

The vagus nerve is the largest autonomic nerve and a major target of stimulation therapies for a wide variety of chronic diseases. However, chronic recording from the vagus nerve has been limited, leading to significant gaps in our understanding of vagus nerve function and therapeutic mechanisms. In this study, we use a carbon nanotube yarn (CNTY) biosensor to chronically record from the vagus nerves of freely moving rats for over 40 continuous hours. Vagal activity was analyzed using a variety of techniques, such as spike sorting, spike-firing rates, and interspike intervals. Many spike-cluster-firing rates were found to correlate with food intake, and the neural-firing rates were used to classify eating and other behaviors. To our knowledge, this is the first chronic recording and decoding of activity in the vagus nerve of freely moving animals enabled by the axon-like properties of the CNTY biosensor in both size and flexibility and provides an important step forward in our ability to understand spontaneous vagus-nerve function.

Indexed as

Nanotubes, CarbonAnimalsRatsRodentiaVagus NerveNanotubes, Carboncarbon nanotubedecodingintrafascicularintraneuralrecordingvagus nerve

Identifiers

PMID35200374
PMCPMC8870245
OpenAlexW4212984283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.