Evidence map›Paper›PMID 35200345›Full record

ArticleBiosensors2022

Development of Stereo NIR-II Fluorescence Imaging System for 3D Tumor Vasculature in Small Animals.

Shih-Po Su, Syue-Liang Lin, Yang-Hsiang Chan, Yi-Jang Lee, Yun-Chen Lee, Pin-Xuan Zeng, Yi-Xuan Li, Muh-Hwa Yang, Huihua Kenny Chiang

Open access · goldAbstract read
In one paragraph

Article in Biosensors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. Development of TheranosticACS applied bio materials · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shih-Po SuDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.ORCID 0000-0001-6908-6090
Syue-Liang LinDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Yang-Hsiang ChanDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
Yi-Jang LeeDepartment of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.ORCID 0000-0002-0340-7557
Yun-Chen LeeDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Pin-Xuan ZengDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Yi-Xuan LiDepartment of Applied Chemistry, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan.
Muh-Hwa YangInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
Huihua Kenny ChiangDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
National Yang Ming Chiao Tung University · TW

Funding

Ministry of Science and Technology MOST109-2221-E-010-001-MY3Ministry of Science and Technology MOST110-2124-M-A49A-501Ministry of Science and Technology MOST110-2811-M-A49A-001
6 · The paper itself

Abstract

Near-infrared-II (NIR-II, 1000-1700 nm) fluorescence imaging boasts high spatial resolution and deep tissue penetration due to low light scattering, reduced photon absorption, and low tissue autofluorescence. NIR-II biological imaging is applied mainly in the noninvasive visualization of blood vessels and tumors in deep tissue. In the study, a stereo NIR-II fluorescence imaging system was developed for acquiring three-dimension (3D) images on tumor vasculature in real-time, on top of the development of fluorescent semiconducting polymer dots (IR-TPE Pdots) with ultra-bright NIR-II fluorescence (1000-1400 nm) and high stability to perform long-term fluorescence imaging. The NIR-II imaging system only consists of one InGaAs camera and a moving stage to simulate left-eye view and right-eye view for the construction of 3D in-depth blood vessel images. The system was validated with blood vessel phantom of tumor-bearing mice and was applied successfully in obtaining 3D blood vessel images with 0.6 mm- and 5 mm-depth resolution and 0.15 mm spatial resolution. The NIR-II stereo vision provides precise 3D information on the tumor microenvironment and blood vessel path.

Indexed as

Fluorescent DyesNeoplasmsAnimalsMiceOptical ImagingPhotonsPolymersFluorescent DyesPolymersNIR-II fluorescence imagingpolymer dotsreconstructionstereo imagingtumor vasculature

Identifiers

PMID35200345
PMCPMC8869613
OpenAlexW4210722139

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.