Evidence map›Paper›PMID 35199896›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2022

Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A.

Yuko Bando, Yu Hou, Lydia Seyfarth, Jannik Probst, Sebastian Götze, Marta Bogacz, Ute A Hellmich, Pierre Stallforth, Maria Mittag, Hans-Dieter Arndt

Open access · hybridAbstract read
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. A mutualistic bacterium rescues a green alga from an antagonist.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. Review
  6. Review
  7. Total Synthesis and Structure Correction of the Cyclic Lipodepsipeptide Orfamide A.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Yuko BandoFriedrich Schiller University Jena, Institute for Organic Chemistry and Macromolecular Chemistry, Humboldtstr. 10, 07743, Jena, Germany.ORCID http://orcid.org/0000-0002-3911-9688
Yu HouFriedrich Schiller University Jena Matthias Schleiden Institute of Genetics, Bioinformatics and Molecular Botany, Am Planetarium 1, 07743, Jena, Germany.ORCID http://orcid.org/0000-0002-8897-2730
Lydia SeyfarthFriedrich Schiller University Jena, Institute for Organic Chemistry and Macromolecular Chemistry, Humboldtstr. 10, 07743, Jena, Germany.
Jannik ProbstFriedrich Schiller University Jena, Institute for Organic Chemistry and Macromolecular Chemistry, Humboldtstr. 10, 07743, Jena, Germany.
Sebastian GötzeLeibniz Institute for Natural Product Research and Infection Biology Hans Knöll Institute, Department of Paleobiotechnology, Beutenbergstraße 11a, 07745, Jena, Germany.ORCID http://orcid.org/0000-0002-4087-0225
Marta BogaczFriedrich Schiller University Jena, Institute for Organic Chemistry and Macromolecular Chemistry, Humboldtstr. 10, 07743, Jena, Germany.
Ute A HellmichFriedrich Schiller University Jena, Institute for Organic Chemistry and Macromolecular Chemistry, Humboldtstr. 10, 07743, Jena, Germany.ORCID http://orcid.org/0000-0001-7162-285X
Pierre StallforthFriedrich Schiller University Jena, Institute for Organic Chemistry and Macromolecular Chemistry, Humboldtstr. 10, 07743, Jena, Germany.ORCID http://orcid.org/0000-0001-7260-9921
Maria MittagFriedrich Schiller University Jena Matthias Schleiden Institute of Genetics, Bioinformatics and Molecular Botany, Am Planetarium 1, 07743, Jena, Germany.ORCID http://orcid.org/0000-0003-3414-9850
Hans-Dieter ArndtFriedrich Schiller University Jena, Institute for Organic Chemistry and Macromolecular Chemistry, Humboldtstr. 10, 07743, Jena, Germany.ORCID http://orcid.org/0000-0002-0792-1422
Friedrich Schiller University Jena · DELeibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI) · DE

Funding

Deutsche Forschungsgemeinschaft Project ID 239748522Deutsche Forschungsgemeinschaft Project-ID 390713860Werner Siemens StiftungYoshida Foundation
6 · The paper itself

Abstract

A total synthesis of the cyclic lipodepsipeptide natural product orfamide A was achieved. By developing a synthesis format using an aminoacid ester building block and SPPS protocol adaptation, a focused library of target compounds was obtained, in high yield and purity. Spectral and LC-HRMS data of all library members with the isolated natural product identified the

Indexed as

Biological ProductsTrypanosoma brucei bruceiTrypanosomiasis, AfricanAnimalsLipopeptidesPeptides, CyclicBiological ProductsLipopeptidesorfamide APeptides, Cyclicalgaenatural productspeptidesstructure-activity relationshiptotal synthesis

Identifiers

PMID35199896
PMCPMC9311703
OpenAlexW4213265224

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.