Evidence map›Paper›PMID 35199827›Full record

Observational studyThe American journal of clinical nutrition2022

Ultra-processed food intake and animal-based food intake and mortality in the Adventist Health Study-2.

Michael J Orlich, Joan Sabaté, Andrew Mashchak, Ujué Fresán, Karen Jaceldo-Siegl, Fayth Miles, Gary E Fraser

Abstract readObservational Study
In one paragraph

Observational study in The American journal of clinical nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
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  8. Review
  9. Using a systems thinking approach to map the global rise of ultra-processed foods in population diets.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
    Review
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  16. Nutritional Criminology: Why the Emerging Research on Ultra-Processed Food Matters to Health and Justice.International journal of environmental research and public health · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Michael J OrlichSchool of Public Health, Loma Linda University, Loma Linda, CA, USA.
Joan SabatéSchool of Public Health, Loma Linda University, Loma Linda, CA, USA.
Andrew MashchakAdventist Health Studies, Loma Linda University Health, Loma Linda, CA, USA.
Ujué FresánSchool of Public Health, Loma Linda University, Loma Linda, CA, USA.
Karen Jaceldo-SieglSchool of Public Health, Loma Linda University, Loma Linda, CA, USA.
Fayth MilesSchool of Public Health, Loma Linda University, Loma Linda, CA, USA.ORCID 0000-0002-4955-7622
Gary E FraserSchool of Public Health, Loma Linda University, Loma Linda, CA, USA.

Funding

Plant-based diets and risk of cancerU01CA152939 · NCI · LOMA LINDA UNIVERSITY · PI FRASER, GARY E. · 2011 to 2015
$5.7M
NCI NIH HHS U01 CA152939
6 · The paper itself

Abstract

backgroundBoth ultra-processed foods and animal-derived foods have been associated with mortality in some studies.

objectivesWe aimed to examine the association of 2 dietary factors (ultra-processed foods and animal-based foods), adjusted for each other, with all-cause mortality.

methodsThe setting is an observational prospective cohort study in North America, recruited from Seventh-day Adventist churches, comprised of 95,597 men and women, yielding an analytic sample of 77,437 participants after exclusions. The exposure of interest was diet measured by FFQ, in particular 2 dietary factors: 1) proportion of dietary energy from ultra-processed foods (other processing levels and specific substitutions in some models) and 2) proportion of dietary energy from animal-based foods (red meat, poultry, fish, and eggs/dairy separately in some models). The main outcome was all-cause mortality. Mortality data through 2015 were obtained from the National Death Index. Analyses used proportional hazards regression.

resultsThere were 9293 deaths. In mutually adjusted continuous linear models of both dietary factors (ultra-processed and animal-based foods), the HR for the 90th compared with the 10th percentile of the proportion of dietary energy from ultra-processed food was 1.14 (95% CI: 1.07, 1.21, comparing 47.7% with 12.1% dietary energy), whereas for animal-based food intake (meats, dairy, eggs) it was 1.01 (95% CI: 0.95, 1.07, comparing 25.0% with 0.4% dietary energy). There was no evidence of interaction (P = 0.36). Among animal-based foods, only red meat intake was associated with mortality (HR: 1.14; 95% CI: 1.08, 1.22, comparing 6.2% with 0% dietary energy).

conclusionsGreater consumption of ultra-processed foods was associated with higher all-cause mortality in this health-conscious Adventist population with many vegetarians. The total of animal-based food consumption (meat, dairy, eggs) was not associated with mortality, but higher red meat intake was. These findings suggest that high consumption of ultra-processed foods may be an important indicator of mortality.

Indexed as

DietFast FoodsAnimalsCohort StudiesEatingFemaleHumansMeatProspective Studiesanimal-baseddietdietary patternmortalityplant-basedprocessedultra-processedvegetarian

Identifiers

PMID35199827
PMCPMC9170476

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.