ArticleeLife2022
Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06939491 (Comparison of Ultrasound-Guided Electrolysis Therapy), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Ultrasound-Guided Electrolysis Therapy (USGET) vs. Sham USGET on Patients With Patellar Tendinopathy: A Randomized Controlled Trial (RCT) Assessing the Effects on Pain, Function, and Tendon Structure Including MRI and Shear-wave Elastography Ultrasound Imaging
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Short-term efficacy of physical interventions for lateral epicondylitis: a network meta-analysis based on multidimensional evaluation of pain and function.Frontiers in pain research (Lausanne, Switzerland) · 2026Pooled it
- Toward an algorithm of percutaneous microelectrolysis: a randomized clinical trial on invasive techniques.Sao Paulo medical journal = Revista paulista de medicina · 2025Trial
- Percutaneous Electrolysis for Patellar Tendinopathy: A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2026Article
- Influence of Time, Intensity, and Total Dose Parameters on the Ultrasound Effects of Percutaneous Electrolysis: An In Vitro Experimental Study.Healthcare (Basel, Switzerland) · 2026Article
- Transcutaneous Electrical Nerve Stimulation (TENS), Interferential Current (IFC) and Percutaneous Needle Electrolysis (PNE) in the treatment of sports-related pain: a scoping review with an evidence gap map.BMC sports science, medicine & rehabilitation · 2026Article
- Ultrasound-guided percutaneous needle electrolysis for musculoskeletal injuries: A scoping review considering implications for athletic populations.South African journal of sports medicine · 2026Review
- Intratendon bioimpedance spectroscopy: a first step exploring reliability and sensitivity to change.PeerJ · 2026Article
- Percutaneous Electrolysis, Percutaneous Peripheral Nerve Stimulation, and Eccentric Exercise for Shoulder Pain and Functionality in Supraspinatus Tendinopathy: A Single-Blind Randomized Clinical Trial.Journal of functional morphology and kinesiology · 2025Article
- Percutaneous Electrolysis for Musculoskeletal Disorders Management in Rehabilitation Settings: A Systematic Review.Healthcare (Basel, Switzerland) · 2025Review
- The P2X7R/NLRP3 inflammasome axis suppresses enthesis regeneration through inflammatory and metabolic macrophage-stem cell cross-talk.Science advances · 2025Article
- Exploring molecular and cellular signaling pathways: Unraveling the pathogenesis of tendinopathy.Journal of orthopaedic translation · 2025Review
- Celastrol suppresses neovascularization in rat aortic vascular endothelial cells stimulated by inflammatory tenocytes via modulating the NLRP3 pathway.Open medicine (Warsaw, Poland) · 2025Article
- The total electric charge and time of application of galvanic currents to macrophages can optimize the release of IL-1β with low cell death.Scientific reports · 2024Article
- Biological and Cellular Effects of Percutaneous Electrolysis: A Systematic Review.Biomedicines · 2024Review
- Multiple ASC-dependent inflammasomes drive differential pro-inflammatory cytokine production in a mouse model of tendinopathy.Bioscience reports · 2024Article
- New Ultrasound-Guided Approach to Access to the Posterolateral Part of Intervertebral Lumbar Discs: A Cadaveric Study.Journal of clinical medicine · 2024Article
- Safety and Effectiveness of Percutaneous Ultrasound-Guided Galvanic Current in Tunnels of Patients with Hidradenitis Suppurativa: A Pilot Study.Dermatology and therapy · 2024Article
- Article
- Application of Percutaneous Needle Electrolysis Does Not Elicit Temperature Changes: An In Vitro Cadaveric Study.International journal of environmental research and public health · 2022Article
- Focus on the Role of the NLRP3 Inflammasome in Multiple Sclerosis: Pathogenesis, Diagnosis, and Therapeutics.Frontiers in molecular neuroscience · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 3 countries.
Funding
Abstract
The NLRP3 inflammasome coordinates inflammation in response to different pathogen- and damage-associated molecular patterns, being implicated in different infectious, chronic inflammatory, metabolic and degenerative diseases. In chronic tendinopathic lesions, different non-resolving mechanisms produce a degenerative condition that impairs tissue healing and which therefore complicates their clinical management. Percutaneous needle electrolysis consists of the application of a galvanic current and is an emerging treatment for tendinopathies. In the present study, we found that galvanic current activates the NLRP3 inflammasome and induces an inflammatory response that promotes a collagen-mediated regeneration of the tendon in mice. This study establishes the molecular mechanism of percutaneous electrolysis that can be used to treat chronic lesions and describes the beneficial effects of an induced inflammasome-related response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.