ReviewPhysiological research2021
Eye pupil - a window into central autonomic regulation via emotional/cognitive processing.
Review in Physiological research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Reviewing digital collaborative interactions with multimodal hyperscanning through an ever-growing database.Frontiers in neuroergonomics · 2026Pooled it
- The Cumulative Effect of a 12-Week Online Mindfulness-Based Meditation Intervention Programme on Autonomic Nerve Functions by Pupillary Light Reflex: A Pilot Randomised Controlled Trial.Stress and health : journal of the International Society for the Investigation of Stress · 2025Trial
- Trial
- Investigating endogenous pain modulation through pupillometry: can pupil size reflect offset analgesia?Pain reports · 2026Article
- The Cost of Social Integration: Distinct Neural Inefficiency in Autistic Children Underlies Symptom Severity.Autism research : official journal of the International Society for Autism Research · 2026Article
- Association between dynamic pupil parameters and corneal sub-basal nerve plexus morphology.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Polarizer-assisted pupillometry through closed eyelids, overcoming pupil position dependence.Journal of biomedical optics · 2026Article
- Setting up an autonomic unit within the neurological department: a position statement of the European Federation of Autonomic Societies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Pupillometry and brain-wide c-Fos mapping uncover multimodal mirror emotional contagion related networks of mice.iScience · 2026Article
- Automatic detection of cognitive events using machine learning and understanding models' interpretations of human cognition.Scientific reports · 2025Article
- Autonomic Nervous System, Cognition, and Emotional Valence During Different Phases of the Menstrual Cycle-A Narrative Review.NeuroSci · 2025Review
- Attachment is in the eye of the beholder: a pupillometry study on emotion processing.Scientific reports · 2025Article
- Mydriasis mediated by local anesthetics: an unexpected adverse event or new therapeutic indication?Therapeutic advances in drug safety · 2025Review
- Emotional contagion to vocal smile revealed by combined pupil reactivity and motor resonance.Scientific reports · 2024Article
- Nonlinear changes in pupillary attentional orienting responses across the lifespan.GeroScience · 2024Article
- Emotional and visual responses to trypophobic images with object, animal, or human body backgrounds: an eye-tracking study.Frontiers in psychology · 2024Article
- Pupillometry and autonomic nervous system responses to cognitive load and false feedback: an unsupervised machine learning approach.Frontiers in neuroscience · 2024Article
- Pupillary Light Reflex and Multimodal Imaging in Patients With Central Serous Chorioretinopathy.Investigative ophthalmology & visual science · 2023Article
- Relationship Between Autonomic Nervous System Activity and Axial Length in Children.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- Does past/current pain change pain experience? Comparing self-reports and pupillary responses.Frontiers in psychology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
If the eyes are windows into the soul, then the pupils represent at least the gateway to the brain and can provide a unique insight into the human mind from several aspects. The changes in the pupil size primarily mediated by different lighting conditions are controlled by the autonomic nervous system regulated predominantly at the subcortical level. Specifically, parasympathetically-linked pupillary constriction is under the Edinger-Westphal nucleus control and sympathetically-mediated pupillary dilation is regulated from the posterior hypothalamic nuclei. However, the changes in the pupil size can be observed at resting state even under constant lighting, these pupillary changes are mediated by global arousal level as well as by various cognitive factors. In this context, autonomic pathways modulating changes in the pupil size in response to the different light levels can be influenced by multiple central descending inputs driving pupillary changes under steady lighting conditions. Moreover, as the pupillary response is involved in emotional (task-evoked pupillary dilation as an index of emotional arousal) and cognitive (task-evoked pupillary dilation as an index of cognitive workload) stimulation, it can be used to detect the impact of mutual subcortical and cortical structures (i.e. overlapping brain structures included in autonomic, emotional and cognitive regulation) on the pupillary innervation system. Thus, complex understanding of the baseline pupil size´ and pupillary dynamics´ mechanisms may provide an important insight into the central nervous system functioning pointing to the pupillometry as a promising tool in the clinical application.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.