ArticleACS chemical biology2022
Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion.
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Article in ACS chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- Getting nuclear size just right - emerging mechanisms regulating nuclear scaling and morphology.Journal of cell science · 2026Review
- Cell and Nuclear Size Is Associated with Chromosomal Instability and Tumorigenicity in Cancer Cells That Undergo Whole Genome Doubling.Cancer research · 2026Article
- Hallachrome, a marine anthraquinone, impairs cell proliferation by acting as a functional mitochondrial uncoupler in A375 melanoma cells.Frontiers in pharmacology · 2026Article
- Replication stress-induced nuclear hypertrophy alters chromatin topology and impacts cancer cell fitness.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A 'Spicy' Mechanotransduction Switch: Capsaicin-Activated TRPV1 Receptor Modulates Osteosarcoma Cell Behavior and Drug Sensitivity.International journal of molecular sciences · 2025Article
- Review
- Tubular Lamin- and Emerin-Lined Nuclear Envelope Invaginations Isolate Chromatin Domains for Gene Expression Regulation.Sub-cellular biochemistry · 2025Review
- A multiparametric screen uncovers FDA-approved small molecules that potentiate the nuclear mechano-dysfunctions in ATR-defective cells.Scientific reports · 2024Article
- Deciphering the role of SAMHD1 in endometrial cancer progression.Biology direct · 2024Article
- Nuclear deformation and dynamics of migrating cells in 3D confinement reveal adaptation of pulling and pushing forces.Science advances · 2024Article
- Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC.iScience · 2024Article
- Nuclear Softness Promotes the Metastatic Potential of Large-Nucleated Colorectal Cancer Cells via the ErbB4-Akt1-Lamin A/C Signaling Pathway.International journal of biological sciences · 2024Article
- Article
- Cyclic Stretch-Induced Mechanical Stress Applied at 1 Hz Frequency Can Alter the Metastatic Potential Properties of SAOS-2 Osteosarcoma Cells.International journal of molecular sciences · 2023Article
- Mechano-induced cell metabolism disrupts the oxidative stress homeostasis of SAOS-2 osteosarcoma cells.Frontiers in molecular biosciences · 2023Article
- Differential contribution of nuclear size scaling mechanisms between Xenopus species.Development, growth & differentiation · 2022Article
- The Nuclear-to-Cytoplasmic Ratio: Coupling DNA Content to Cell Size, Cell Cycle, and Biosynthetic Capacity.Annual review of genetics · 2022Review
- Nuclear size rectification: A potential new therapeutic approach to reduce metastasis in cancer.Frontiers in cell and developmental biology · 2022Review
- Specificity of Nuclear Size Scaling in Frog Erythrocytes.Frontiers in cell and developmental biology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 6 institutions in 4 countries.
Sylvain TollisInstitute of Biomedicine, University of Eastern Finland, Kuopio 70210, Finland.ORCID 0000-0002-7301-4556
Andrea RizzottoThe Institute of Cell Biology, University of Edinburgh, Kings Buildings, Michael Swann Buildings, Max Born Crescent, Edinburgh EH9 3BF, U.K.
Nhan T PhamInstitute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, Edinburgh EH9 3BF, U.K.ORCID 0000-0003-1620-2910
Sonja KoivukoskiInstitute of Biomedicine, University of Eastern Finland, Kuopio 70210, Finland.
Aishwarya SivakumarThe Institute of Cell Biology, University of Edinburgh, Kings Buildings, Michael Swann Buildings, Max Born Crescent, Edinburgh EH9 3BF, U.K.
Steven ShaveInstitute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, Edinburgh EH9 3BF, U.K.ORCID 0000-0001-6996-3663
Jan WildenhainInstitute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, Edinburgh EH9 3BF, U.K.
Nikolaj ZulegerThe Institute of Cell Biology, University of Edinburgh, Kings Buildings, Michael Swann Buildings, Max Born Crescent, Edinburgh EH9 3BF, U.K.
Jeremy T KeysNancy E. and Peter C. Meinig School of Biomedical Engineering & Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, United States.
Jayne CulleyEdinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, U.K.
Yijing ZhengInstitute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, Edinburgh EH9 3BF, U.K.
Jan LammerdingNancy E. and Peter C. Meinig School of Biomedical Engineering & Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, New York 14853, United States.
Neil O CarragherEdinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, U.K.
Valerie G BruntonEdinburgh Cancer Research UK Centre, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XR, U.K.ORCID 0000-0002-7778-8794
Leena LatonenInstitute of Biomedicine, University of Eastern Finland, Kuopio 70210, Finland.
Manfred AuerInstitute of Quantitative Biology, Biochemistry and Biotechnology, University of Edinburgh, Edinburgh EH9 3BF, U.K.ORCID 0000-0001-8920-3522
Mike TyersInstitute for Research in Immunology and Cancer, Université de Montréal, Montréal, Québec H3T 1J4, Canada.ORCID 0000-0002-9713-9994
Eric C SchirmerThe Institute of Cell Biology, University of Edinburgh, Kings Buildings, Michael Swann Buildings, Max Born Crescent, Edinburgh EH9 3BF, U.K.
University of Edinburgh · GBWellcome Centre for Cell Biology · GBEdinburgh Cancer Research · GBUniversity of Eastern Finland · FICornell University · USInstitute for Research in Immunology and Cancer · CA
Funding
Project 3: Physical and Metabolic Constraints of Cancer Cell InvasionU54CA210184 · NCI · CORNELL UNIVERSITY · PI FISCHBACH, CLAUDIA · 2016 to 2020
$10.2MNuclear mechanics and mechanotransduction in muscular laminopathiesR01HL082792 · NHLBI · CORNELL UNIVERSITY · PI LAMMERDING, JAN · 2007 to 2023
$4.8MNuclear mechanobiology in confined migration (Equipment Supplement 2023)R01GM137605 · NIGMS · CORNELL UNIVERSITY · PI LAMMERDING, JAN · 2020 to 2023
$1.6MMedical Research Council MC_G0802522Medical Research Council MR/R018073/1NCI NIH HHS U54 CA210184NHLBI NIH HHS R01 HL082792NIGMS NIH HHS R01 GM137605Wellcome Trust 085178Wellcome Trust 092076Wellcome Trust 095209Wellcome Trust 201531/Z/16/Z
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdenocarcinomaProstatic NeoplasmsCell Line, TumorCell MovementHumansMaleNeoplasm Invasiveness
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What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.