ArticleEuropean journal of nuclear medicine and molecular imaging2022
Processing speed dysfunction is associated with functional corticostriatal circuit alterations in childhood epilepsy with centrotemporal spikes: a PET and fMRI study.
Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04954729 (Association of Processing Speed Dysfunction and Brain Functional Abnormality in Childhood Epilepsy With Centrotemporal Spikes), which is not on this map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association of Processing Speed Dysfunction and Brain Functional Abnormality in Childhood Epilepsy With Centrotemporal Spikes
Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Cerebellar hypermetabolism disrupts fronto-cerebellar resting-state functional connectivity and associated executive compensation.Translational psychiatry · 2026Article
- Diffusion Tractography Biomarker for Epilepsy Severity in Children With Drug-Resistant Epilepsy.Annals of clinical and translational neurology · 2026Article
- Molecular imaging based biophysical changes of striatum closely associated with cognitive impairment in childhood self-limited epilepsy with centrotemporal spikes.European journal of nuclear medicine and molecular imaging · 2025Article
- Establishment of a normal control model of children's brain 18-fluorodeoxyglucose positron emission tomography and analysis of the changing pattern in patients aged 0-14 years.Quantitative imaging in medicine and surgery · 2024Article
- Nuclear psychiatric imaging: the trend of precise diagnosis for mental disorders.European journal of nuclear medicine and molecular imaging · 2024Article
- Simultaneous high-resolution whole-brain MR spectroscopy and [European journal of nuclear medicine and molecular imaging · 2024Article
- Network Analysis of ADHD Symptoms and Cognitive Profiles in Children.Neuropsychiatric disease and treatment · 2023Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeEpilepsy with centrotemporal spikes (ECTS) is the most common epilepsy syndrome in children and usually presents with cognitive dysfunctions. However, little is known about the processing speed dysfunction and the associated neuroimaging mechanism in ECTS. This study aims to investigate the brain functional abnormality of processing speed dysfunction in ECTS patients by using the
methodsThis prospective study recruited twenty-eight ECTS patients who underwent the
resultsCompared with healthy controls, ECTS patients showed normal intelligence quotient but significantly decreased PSI (P = 0.04). PET analysis showed significantly decreased SUVRs within bilateral caudate, putamen, pallidum, left NAc, right rostral middle frontal gyrus, and frontal pole of ECTS patients (P < 0.05). Rs-fMRI analysis showed absolute values of 20 FCs were significantly decreased in ECTS patients compared with MRI controls, which connected 16 distinct ROIs. The average SUVR of right caudate and the average of 20 FCs were positively correlated with PSI in ECTS patients (P = 0.034 and P = 0.005, respectively).
conclusionThis study indicated that ECTS patients presented significantly reduced PSI, which is closely associated with decreased SUVR and FC of cortical-striatal circuit. Caudate played an important role in processing speed dysfunction. CLINICAL
trial registrationNCT04954729; registered on July 8, 2021, public site, https://clinicaltrials.gov/ct2/show/NCT04954729.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.