Evidence map›Paper›PMID 35199214›Full record

Observational studyAesthetic plastic surgery2022

A Novel Technique Combining Human Acellular Dermal Matrix (HADM) and Enriched Platelet Therapy (EPT) for the Treatment of Vaginal Laxity: A Single-Arm, Observational Study.

Fang Yang, Yin Liu, Hong Xiao, Jiaying Ma, Huanying Cun, Chengdao Wu

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Aesthetic plastic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Fang YangDepartment of Dermatology, Aesthetic Gynaecology and Plastic surgery, Yunnan Wushi Jiamei cosmetic Hospital, No.300, Dongsi street, Kunming, 650000, Yunnan Province, China.
Yin LiuDepartment of Plastic Surgery, The 2nd Hospital affiliated to Kunming Medical University, No.374, Dianmian street, Kunming, 650000, Yunnan Province, China.
Hong XiaoDepartment of Plastic Surgery, The 2nd Hospital affiliated to Kunming Medical University, No.374, Dianmian street, Kunming, 650000, Yunnan Province, China.
Jiaying MaDepartment of Dermatology, Aesthetic Gynaecology and Plastic surgery, Yunnan Wushi Jiamei cosmetic Hospital, No.300, Dongsi street, Kunming, 650000, Yunnan Province, China.
Huanying CunDepartment of Dermatology, Aesthetic Gynaecology and Plastic surgery, Yunnan Wushi Jiamei cosmetic Hospital, No.300, Dongsi street, Kunming, 650000, Yunnan Province, China.
Chengdao WuDepartment of Dermatology, Aesthetic Gynaecology and Plastic surgery, Yunnan Wushi Jiamei cosmetic Hospital, No.300, Dongsi street, Kunming, 650000, Yunnan Province, China. 997447498@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is a paucity of knowledge about cosmetic vaginal tightening procedures; therefore, the present study aimed to describe the clinical effects of a novel combination technique of human acellular dermal matrix (HADM) and enriched platelet therapy (EPT) for the treatment of vaginal laxity.

methodsThis single-arm, observational study was conducted on 52 patients with grade II to III vaginal relaxation. HADM biological band (U-shaped) was implanted in these patients by submucosal puncture in vagina under anesthesia. This was followed by thrice administration of EPT injection, once at the time surgery followed by each dose at a time interval of one month. Patients were followed up for a period of 6 months based on Female Sexual Function Index (FSFI) and Vaginal Health Index (VHI) scores. Patient satisfaction was measured using Visual Analogue Score (VAS).

resultsAbout 52 women with median age of 39 years were included in the study. The average time reported to complete HADM surgery was reported as 27 minutes. Following implantation, it was found that labia minora was significantly closed and perineal length was increased from 1.5 to 2.2 cm. Moreover, there was improvement in elasticity, contractility and lubricity of vaginal mucosa. The sexual function scores from pre- to post-surgery were significantly increased (7.95 vs. 30.09; p value: <0.001). The mean VHI score also increased significantly after 6 months of treatment (mean ± S.D. before vs after treatment: 11.2 ± 3.3 vs. 19.6 ± 4.1, P < 0.0001). The mean VAS after surgery was 1.61 ± 0.31. About 96% of the patients did not feel any pain after treatment at 6-month follow-up. No adverse effects were reported in this study.

conclusionsThese findings supported that combination treatment with HADM and EPT was safe and associated with both improved vaginal laxity and sexual function. These results may provide a novel surgical technique for this prevalent and undertreated condition. LEVEL OF EVIDENCE IV: Therapeutic Study This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Indexed as

Acellular DermisAdultElasticityFemaleHumansPatient SatisfactionTreatment OutcomeVaginaVulvaEPTHADMSurgicalVaginal laxity

Identifiers

PMID35199214
PMCPMC9512737

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.