Evidence map›Paper›PMID 35199092›Full record

ReviewJID innovations : skin science from molecules to population health2022

Cannabinoids for the Treatment of Dermatologic Conditions.

Torunn E Sivesind, Jalal Maghfour, Hope Rietcheck, Kevin Kamel, Ali S Malik, Robert P Dellavalle

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in JID innovations : skin science from molecules to population health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05651607 (Evaluation of the Efficacy of CANNABIDIOL on the Pruritus in Children With Hereditary Epidermolysis Bullosa), which is not on this map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05651607 phase2completednot on this mapstarted 2023, after this paper: background citation

Evaluation of the Efficacy of CANNABIDIOL on the Pruritus in Children With Hereditary Epidermolysis Bullosa

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2023 to 2023Enrolled10ConditionsHereditary Epidermolysis BullosaArmsCannabidiol
3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Torunn E SivesindDepartment of Dermatology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Jalal MaghfourDepartment of Dermatology and Skin Care, Henry Ford Health System, Detroit, Michigan, USA.
Hope RietcheckDepartment of Dermatology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Kevin KamelSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Ali S MalikDepartment of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Robert P DellavalleDepartment of Dermatology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
University of Colorado Anschutz Medical Campus · USHenry Ford Health System · USUnited States Department of Veterans Affairs · USWake Forest University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In recent years, cannabinoid (CB) products have gained popularity among the public. The anti-inflammatory properties of CBs have piqued the interest of researchers and clinicians because they represent promising avenues for the treatment of autoimmune and inflammatory skin disorders that may be refractory to conventional therapy. The objective of this study was to review the existing literature regarding CBs for dermatologic conditions. A primary literature search was conducted in October 2020, using the PubMed and Embase databases, for all articles published from 1965 to October 2020. Review articles, studies using animal models, and nondermatologic and pharmacologic studies were excluded. From 248 nonduplicated studies, 26 articles were included. There were 13 articles on systemic CBs and 14 reports on topical CBs. Selective CB receptor type 2 agonists were found to be effective in treating diffuse cutaneous systemic sclerosis and dermatomyositis. Dronabinol showed efficacy for trichotillomania. Sublingual cannabidiol and Δ-9-tetrahydrocannabinol were successful in treating the pain associated with epidermolysis bullosa. Available evidence suggests that CBs may be effective for the treatment of various inflammatory skin disorders. Although promising, additional research is necessary to evaluate efficacy and to determine dosing, safety, and long-term treatment guidelines.

Indexed as

2-AG, 2-arachidonoylglycerolACR-CRISS, American College of Rheumatology-combined response index in diffuse cutaneous systemic sclerosisAEA, anandamideCB1R, cannabinoid receptor 1CB2R, cannabinoid receptor 2CB, cannabinoidCBD, cannabidiolCDASI, cutaneous dermatomyositis disease area and severity indexDM, dermatomyositisECS, endocannabinoid systemKC, keratinocyteMRSS, modified Rodnan skin thickness scoreN-PEA, N-palmitoylethanolamideQOLHEQ, Quality of Life Hand Eczema QuestionnaireRCT, randomized controlled trialSSc, systemic sclerosisVAS, Visual Analog ScoreΔ9-THC, delta-9-tetrahydrocannabinol

Identifiers

PMID35199092
PMCPMC8841811
OpenAlexW4205570724

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.