Evidence map›Paper›PMID 35199089›Full record

ArticleJID innovations : skin science from molecules to population health2022

Malignant T Cell Activation by a

Carina A Dehner, William E Ruff, Teri Greiling, Márcia S Pereira, Sylvio Redanz, Jennifer McNiff, Michael Girardi, Martin A Kriegel

Open access · goldAbstract read
In one paragraph

Article in JID innovations : skin science from molecules to population health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Role of Antigenic Stimulation in Cutaneous T-Cell Lymphomas.The Journal of investigative dermatology · 2024
    Review
  7. Article
  8. What Is New in Cutaneous T Cell Lymphoma?Current oncology reports · 2023
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Carina A DehnerDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
William E RuffDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Teri GreilingDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Márcia S PereiraDepartment of Translational Rheumatology and Immunology, Institute of Musculoskeletal Medicine, University of Münster, Münster, Germany.
Sylvio RedanzDepartment of Translational Rheumatology and Immunology, Institute of Musculoskeletal Medicine, University of Münster, Münster, Germany.
Jennifer McNiffDepartment of Dermatopathology, Yale University School of Medicine, New Haven, Connecticut, USA.
Michael GirardiDepartment of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA.
Martin A KriegelDepartment of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
University of Münster · DEYale University · USOregon Health & Science University · USWashington University in St. Louis · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
INTERDISCIPLINARY IMMUNOLOGY TRAINING PROGRAMT32AI007019 · NIAID · YALE UNIVERSITY · PI Carrie L. Lucas, David G. Schatz · 1985 to 2026
$14.4M
Human Gut Commensal Cross-reactivity in Antiphospholipid SyndromeR01AI118855 · NIAID · YALE UNIVERSITY · PI KRIEGEL, MARTIN A., MEFFRE, ERIC · 2015 to 2019
$2.1M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS R01 AI118855NIAID NIH HHS T32 AI007019
6 · The paper itself

Abstract

Cutaneous T-cell lymphoma (CTCL) is a life-debilitating malignancy of lymphocytes homing to the skin. Although CTCL is thought to arise from a combination of genetic, epigenetic, and environmental factors, specific triggers are unclear. The skin is colonized by a unique microbiota and is heavily influenced by its interactions. We hypothesized that adaptive immune responses to skin commensals lead to clonal T-cell proliferation and transformation in the appropriate genetic background. We therefore collected lesional and nonlesional skin microbiota from patients with CTCL to study T cell interactions using skin T cell explants and peripheral, skin-homing CD4

Indexed as

ASV, amplicon sequence variantCLA, cutaneous lymphocyte‒associated antigenCTCL, cutaneous T-cell lymphomaMF, mycosis fungoidesrRNA, ribosomal RNASTAT3, signal transducer and activator of transcription 3

Identifiers

PMID35199089
PMCPMC8844718
OpenAlexW4200063174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.