Evidence map›Paper›PMID 35198957›Full record

ReviewMaterials today. Bio2022

Towards principled design of cancer nanomedicine to accelerate clinical translation.

Mohammad Souri, M Soltani, Farshad Moradi Kashkooli, Mohammad Kiani Shahvandi, Mohsen Chiani, Fatemeh Sadat Shariati, Mohammad Reza Mehrabi, Lance L Munn

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Applications of Nanobiotechnology in Medicine.Life (Basel, Switzerland) · 2026
    Review
  10. Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Lessons Learned from Liver-on-Chip Platform.Annals of biomedical engineering · 2025
    Review
  19. Review
  20. Review

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohammad SouriDepartment of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran.
M SoltaniDepartment of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran.
Farshad Moradi KashkooliDepartment of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran.
Mohammad Kiani ShahvandiDepartment of Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran.
Mohsen ChianiDepartment of Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.
Fatemeh Sadat ShariatiDepartment of Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.
Mohammad Reza MehrabiDepartment of Nanobiotechnology, Pasteur Institute of Iran, Tehran, Iran.
Lance L MunnSteele Laboratories, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, 02114, USA.

Funding

Targeting physical stress-driven mechanisms to overcome glioblastoma treatment resistanceU01CA261842 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, RAKESH K., MUNN, LANCE L. · 2021 to 2025
$3.1M
Vascularized tumor explants for drug testingR01CA247441 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI MUNN, LANCE L. · 2021 to 2025
$1.9M
NCI NIH HHS R01 CA247441NCI NIH HHS U01 CA261842
6 · The paper itself

Abstract

Nanotechnology in medical applications, especially in oncology as drug delivery systems, has recently shown promising results. However, although these advances have been promising in the pre-clinical stages, the clinical translation of this technology is challenging. To create drug delivery systems with increased treatment efficacy for clinical translation, the physicochemical characteristics of nanoparticles such as size, shape, elasticity (flexibility/rigidity), surface chemistry, and surface charge can be specified to optimize efficiency for a given application. Consequently, interdisciplinary researchers have focused on producing biocompatible materials, production technologies, or new formulations for efficient loading, and high stability. The effects of design parameters can be studied

Indexed as

CFL, Cell-free layerCGMD, Coarse-grained molecular dynamicClinical translationDPD, Dissipative particle dynamicDrug deliveryDrug loadingECM, Extracellular matrixEPR, Permeability and retentionIFP, Interstitial fluid pressureMD, Molecular dynamicMDR, Multidrug resistanceMEC, Minimum effective concentrationMMPs, Matrix metalloproteinasesMPS, Mononuclear phagocyte systemMTA, Multi-tadpole assembliesMTC, Minimum toxic concentrationNanomedicineNanoparticle designRBC, Red blood cellTAF, Tumor-associated fibroblastTAM, Tumor-associated macrophageTIMPs, Tissue inhibitor of metalloproteinasesTME, Tumor microenvironmentTumor microenvironment

Identifiers

PMID35198957
PMCPMC8841842

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.