ReviewCJC open2022
The Cardiovascular System in Heat Stroke.
Review in CJC open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 67 citations in OpenAlex.
- Sex differences in the impact of extreme heat on cardiovascular disease outcomes: a systematic review and meta-analysis.Environmental health : a global access science source · 2025Pooled it
- Unlocking the potential of circadian biology for cardiovascular health.Physiological reviews · 2026Review
- Associations Between Acute Heat Exposure and Hospitalization for Takotsubo Syndrome in the State of California, 2006 to 2019.Journal of the American Heart Association · 2026Article
- Heat Stroke or Acute Coronary Syndrome? A Summer Collapse With an Unexpected Cardiac Twist.Cureus · 2026Article
- Mechanisms and Intervention Strategies for Heat Stroke-Associated Myocardial Dysfunction: A Narrative Review.The western journal of emergency medicine · 2026Review
- Heat-Related Illness and Heatstroke: A Narrative and Clinical Review for Emergency Clinicians.Cureus · 2026Review
- Acute Heat Exposure-Related Illness: A Unified Emergency Medicine Framework for Hot Baths, Hot Springs, and Saunas-A Narrative Review.Journal of clinical medicine · 2026Review
- Heat stress and social dialogue in Spain.Industrial health · 2026Article
- Heat stroke and the liver: mechanisms of injury and therapeutic strategies.European journal of medical research · 2026Review
- The diagnostic value of multimodal imaging for myocardial injury in heat stroke.Frontiers in cardiovascular medicine · 2026Article
- UHR as a systemic sensor of cumulative heat exposure and subclinical cardiovascular injury: evidence from 64,088 adults.Frontiers in public health · 2026Article
- Machine Learning-Based Prediction of Heatwave-Related Hospitalizations: A Case Study in Matam, Senegal.International journal of environmental research and public health · 2025Article
- The Singapore Physical Activity Readiness Questionnaire 2021 (SPARQ 2021)-Results of Public Feedback.Healthcare (Basel, Switzerland) · 2025Article
- Environment-induced heat stress causes ventricular-dependent biochemical changes in the heart in female pigs.Physiological reports · 2025Article
- Scorching Heat and Fragile Hearts: Hidden Cardiovascular RisksBalkan medical journal · 2025Article
- Nonlinear exposure-response associations of daytime, nighttime, and day-night compound heatwaves with mortality amid climate change.Nature communications · 2025Article
- Hyperthermia-induced sudden death: Morphological insights from the lung and heart in an experimental study of Wistar rats.Open veterinary journal · 2025Article
- One day of environment-induced heat stress damages the murine myocardium.American journal of physiology. Heart and circulatory physiology · 2024Article
- Climate change's implications for practice: Pharmacologic considerations of heat-related illness.The Nurse practitioner · 2024Article
- Thermal Comfort Conditions and Mortality in Brazil.International journal of environmental research and public health · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In June 2021, western Canada experienced an unprecedented heat wave, breaking dozens of temperature records. As a result, the region had a significant uptick in sudden deaths, emergency department visits, and hospital admissions. Under thermal stress, the human body achieves heat dissipation through evaporation of sweat and increased cutaneous blood flow. When these mechanisms are overwhelmed, the core body temperature rises, which leads to heat stroke, a life-threatening syndrome of hyperthermia and central nervous system dysfunction in the setting of an environmental thermal load. Heat dissipation relies on an intact cardiovascular system to dilate cutaneous vasculature and increase cardiac output. Individuals with impaired cardiovascular function have a limited ability to increase stroke volume, cardiac output, and blood flow to the skin, increasing the risk of heat stroke. In turn, these patients, whose cardiac condition is already compromised, are susceptible to cardiovascular complications of heat stroke, including arrhythmias, myocardial ischemia, heart failure, shock, and sudden death. Indeed, the majority of excess deaths during heat waves are cardiovascular in origin, highlighting the impact the cardiovascular system has on the development of heat stroke, and vice versa. This review summarizes the current understanding of the interaction between the cardiovascular system and heat stroke, including the pathophysiology, cardiovascular complications, and treatment.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.