Evidence map›Paper›PMID 35198925›Full record

ArticleEClinicalMedicine2022

Paediatric chronic pain prevalence in low- and middle-income countries: A systematic review and meta-analysis.

Zi Wei Liao, Chi Le, J Matthew Kynes, Jonathan A Niconchuk, Emilia Pinto, Heather E Laferriere, Camila B Walters

Open access · goldAbstract read
In one paragraph

Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  5. Review
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  7. Prevalence of neurocognitive impairments in adults with chronic pain: A cross-sectional study.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Zi Wei Liao224 Eskind Biomedical Library and Learning Center, Vanderbilt University School of Medicine, Nashville, TN 37240-7939, USA.
Chi Le224 Eskind Biomedical Library and Learning Center, Vanderbilt University School of Medicine, Nashville, TN 37240-7939, USA.
J Matthew KynesVanderbilt University Medical Center, 2200 Children's Way, Nashville, TN 37232, USA.
Jonathan A NiconchukVanderbilt University Medical Center, 2200 Children's Way, Nashville, TN 37232, USA.
Emilia PintoMaputo Central Hospital, 1653 Avenida Eduardo Mondlane, Maputo, Mozambique.
Heather E Laferriere224 Eskind Biomedical Library and Learning Center, Vanderbilt University, Nashville, TN 37240-7939, USA.
Camila B WaltersVanderbilt University Medical Center, 2200 Children's Way, Nashville, TN 37232, USA.
Vanderbilt University · USVanderbilt University Medical Center · USMaputo Central Hospital · MZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic pain is a leading cause of morbidity in children and adolescents globally, with a significant impact on quality of life. This is the first systematic review and meta-analysis on paediatric chronic pain in low- and middle-income countries (LMICs).

methodsFollowing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we searched MEDLINE (via PubMed), Embase, CINAHL, PsycINFO, Web of Science, Cochrane Database of Systematic Reviews, and the WHO Global Index Medicus for all studies published prior to January 7, 2022. Articles published in all languages that included populations age 19 years and under living in LMICs were considered. Chronic pain was defined as persistent or recurrent pain that is present for ≥3 months, per the International Classification of Diseases (ICD-11) definition. Summary data were extracted from published reports and evaluated with mixed-effects regression analysis. PROSPERO Record ID: CRD42021227967.

findingsOf the 2875 studies identified, 70 articles were reviewed, with 27 studies representing 20 LMICs eligible for analysis. The average prevalence for each pain type reported with 95% confidence interval is as follows: general/multi-site/any 20% (16-25), musculoskeletal (MSK) pain 9% (7-13), abdominal pain 7% (5-10), headache 4% (2-10), and fibromyalgia per American College of Rheumatology or Yunus and Masi criteria 3% (1-10). Overall, a pooled mean of 8% chronic pain was estimated across all studies. A significantly high level of heterogeneity was found across all studies (

interpretationThe characterization of paediatric chronic pain in low- and middle-income countries suffers from a paucity of data and significant heterogeneity in the assessment methods. Understanding the global burden of chronic pain in this group should be prioritized.

fundingNone.

Indexed as

AdolescentsChildrenChronic painLow- and middleincome countriesPaediatric painPediatric pain

Identifiers

PMID35198925
PMCPMC8850335
OpenAlexW4211227115

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.