Evidence map›Paper›PMID 35198918›Full record

ArticleEClinicalMedicine2022

Acute kidney injury, persistent kidney disease, and post-discharge morbidity and mortality in severe malaria in children: A prospective cohort study.

Ruth Namazzi, Anthony Batte, Robert O Opoka, Paul Bangirana, Andrew L Schwaderer, Zachary Berrens, Dibyadyuti Datta, Michael Goings, John M Ssenkusu, Stuart L Goldstein and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 2 pooled it
13.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 69 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Malaria-Associated Acute Kidney Injury: A Key Driver of Mortality in Endemic Regions.International journal of nephrology and renovascular disease · 2026
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 2 countries.

Ruth NamazziDepartment of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda.
Anthony BatteChild Health and Development Center, Makerere University College of Health Sciences, Kampala, Uganda.
Robert O OpokaDepartment of Paediatrics and Child Health, Makerere University College of Health Sciences, Kampala, Uganda.
Paul BangiranaGlobal Health Uganda, Kampala, Uganda.
Andrew L SchwadererDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Zachary BerrensDepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.
Dibyadyuti DattaRyan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, 1044 W. Walnut St., Indianapolis, IN, USA.
Michael GoingsRyan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, 1044 W. Walnut St., Indianapolis, IN, USA.
John M SsenkusuDepartment of Epidemiology and Biostatistics, Makerere University School of Public Health, Kampala, Uganda.
Stuart L GoldsteinCincinnati Children's Hospital, Cincinnati, OH, USA.
Chandy C JohnRyan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, 1044 W. Walnut St., Indianapolis, IN, USA.
Andrea L ConroyRyan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, 1044 W. Walnut St., Indianapolis, IN, USA.
Indiana University School of MedicineWorld Health Organization - Uganda · UGCenter for Global Health · USMakerere University · UGCincinnati Children's Hospital Medical Center · US

Funding

Severe Malaria And Risk to The Brain (SMART Brain)R01NS055349 · NINDS · UNIVERSITY OF MINNESOTA · PI Chandy C. John, Ruth Namazzi · 2008 to 2026
$11.2M
Research training in infection, nutrition and neurodevelopment in UgandaD43TW010928 · FIC · INDIANA UNIVERSITY INDIANAPOLIS · PI Chandy C. John · 2018 to 2026
$1.9M
FIC NIH HHS D43 TW010928NINDS NIH HHS R01 NS055349
6 · The paper itself

Abstract

backgroundGlobally, 85% of acute kidney injury (AKI) cases occur in low-and-middle-income countries. There is limited information on persistent kidney disease (acute kidney disease [AKD]) following severe malaria-associated AKI.

methodsBetween March 28, 2014, and April 18, 2017, 598 children with severe malaria and 118 community children were enrolled in a two-site prospective cohort study in Uganda and followed up for 12 months. The Kidney Disease: Improving Global Outcomes (KDIGO) criteria were used to define AKI (primary exposure) and AKD at 1-month follow-up (primary outcome). Plasma neutrophil gelatinase-associated lipocalin (NGAL) was assessed as a structural biomarker of AKI.

findingsThe prevalence of AKI was 45·3% with 21·5% of children having unresolved AKI at 24 h. AKI was more common in Eastern Uganda. In-hospital mortality increased across AKI stages from 1·8% in children without AKI to 26·5% with Stage 3 AKI (

interpretationChildren with severe malaria-associated AKI are at risk of AKD and post-discharge mortality.

fundingThis work was supported by the National Institutes of Health National Institute of Neurological Disorders and Stroke (R01NS055349 to CCJ) and the Fogarty International Center (D43 TW010928 to CCJ), and a Ralph W. and Grace M. Showalter Young Investigator Award to ALC.

Indexed as

Acute kidney diseaseAcute kidney injuryBlackwater feverCerebral malariaDisabilityMalariaMortalityNeurologic deficitNGALSub-Saharan Africa

Identifiers

PMID35198918
PMCPMC8850340
OpenAlexW4211138849

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.