ArticleAdvances in radiation oncology
Four-Dimensional Computed Tomography-Based Correlation of Respiratory Motion of Lung Tumors With Implanted Fiducials and an External Surrogate.
Article in Advances in radiation oncology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- M4DTrack: A DICOM-Based Imaging Informatics Workflow for User-Supervised 4DCT Lung Tumor Motion Reporting.Journal of imaging informatics in medicine · 2026Article
- Quantitative perfusion imaging from non-contrast micro-ct for pulmonary embolism evaluation in preclinical models.Physics in medicine and biology · 2026Article
- Article
- Initial Experience with Correlation Object-Based DRR Targeting Using Stereoscopic X-Ray Imaging in Lung SBRT.Cancers · 2026Article
- High-speed bioimpedance-based gating system for radiotherapy: Prototype and proof of principle.Journal of applied clinical medical physics · 2024Article
- Deep learning-based target decomposition for markerless lung tumor tracking in radiotherapy.Medical physics · 2024Article
- Intra- and inter-fractional variations of tumors with fiducial markers measured using respiratory-correlated computed tomography images for respiratory gated lung stereotactic body radiation therapy.Journal of applied clinical medical physics · 2024Article
- Article
- Deep inspiration breath hold real-time tumor-tracking radiation therapy (DBRT) as a novel stereotactic body radiation therapy approach for lung tumors.Scientific reports · 2024Article
- Development of a prediction model for target positioning by using diaphragm waveforms extracted from CBCT projection images.Journal of applied clinical medical physics · 2023Article
- Evaluation of tumour motion and internal/external correlation in lung SABR.The British journal of radiology · 2023Article
- Can bronchoscopically implanted anchored electromagnetic transponders be used to monitor tumor position and lung inflation during deep inspiration breath-hold lung radiotherapy?Medical physics · 2022Article
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Authors and funding
14 authors.
Funding
Abstract
purposeOur purpose was to assess the suitability of airway-implanted internal fiducial markers and an external surrogate of respiratory motion for motion management during radiation therapy of lung tumors. METHODS AND MATERIALS: We analyzed 4-dimensional computed tomography scans acquired during radiation therapy simulation for 28 patients with lung tumors who had anchored fiducial markers bronchoscopically implanted inside small airways in or near the tumor in a prospective trial. We used a linear mixed model to build population-based correlative models of tumor and surrogate motion. The first 24 of the 28 patients were used to build correlative models, and 4 of the 28 consecutive patients were excluded and used as an internal validation cohort. Of the 24 patients from the model building cohort, all were used for the models based on the internal fiducial. The external surrogate was completely visualized in 11 patients from the model building cohort, so only those were used for the models based on the external surrogate. Furthermore, we determined the predicted residual error sum of squares for our correlative models, which may serve as benchmarks for future research.
resultsThe motion of the internal fiducials was significantly associated with the tumor motion in the anterior-posterior (
conclusionsThe internal fiducials appear to be more reliable predictors of lung tumor motion than the external surrogate. The suitability of such airway-implanted internal fiducial markers for advanced motion management techniques should be further investigated. Although the external surrogate seems to be less reliable, its wide availability and noninvasive application support its clinical utility, albeit the greater uncertainty will need to be compensated for.
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