Evidence map›Paper›PMID 35198658›Full record

ArticleBone reports2022

Contemporary kidney transplantation has a limited impact on bone microarchitecture.

Catarina Meng, Hanne Skou Jørgensen, Lieve Verlinden, Nathalie Bravenboer, Henriette de Loor, Patrick C D'Haese, Geert Carmeliet, Pieter Evenepoel

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Catarina MengDepartment of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium.
Hanne Skou JørgensenDepartment of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium.
Lieve VerlindenDepartment of Chronic Diseases and Metabolism, Laboratory of Clinical and Experiment Endocrinology, KU Leuven, Leuven, Belgium.
Nathalie BravenboerDepartment of Clinical Chemistry, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam Movement Sciences, Amsterdam, the Netherlands.
Henriette de LoorDepartment of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium.
Patrick C D'HaeseLaboratory of Pathophysiology, University of Antwerp, Wilrijk, Belgium.
Geert CarmelietDepartment of Chronic Diseases and Metabolism, Laboratory of Clinical and Experiment Endocrinology, KU Leuven, Leuven, Belgium.
Pieter EvenepoelDepartment of Microbiology, Immunology and Transplantation, Nephrology and Renal Transplantation Research Group, KU Leuven, Leuven, Belgium.
KU Leuven · BEUniversidade do Porto · PTUniversity of Antwerp · BEVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone microarchitecture is an important component of bone quality and disturbances may reduce bone strength and resistance to trauma. Kidney transplant recipients have an excess risk of fractures, and bone loss affecting both trabecular and cortical bone compartments have been demonstrated after kidney transplantation. The primary aim of this study was to investigate the impact of kidney transplantation on trabecular and cortical bone microarchitecture, assessed by histomorphometry and micro computed tomography (μCT). Iliac crest bone biopsies, analyzed by bone histomorphometry and μCT, were performed at time of kidney transplantation and 12 months post-transplantation in an unselected cohort of 30 patients. Biochemical markers of mineral metabolism and bone turnover were measured at both time-points. At 12 months post-transplantation, bone turnover was low in 5 (17%) and normal in 25 (83%) patients. By histomorphometry, bone remodeling normalized, with decreases in eroded perimeters (4.0 to 2.1%,

Indexed as

2D, two-dimensional3D, three-dimensionalBALP, bone-specific alkaline phosphataseBMD, bone mineral densityBone densityBone histomorphometryChronic kidney disease – mineral and bone disorderCKD, chronic kidney diseaseDXA, dual-energy x-ray absorptiometryeGFR, estimated glomerular filtration rateHRpQCT, high-resolution peripheral quantitative computed tomographyKidney transplantationOsteoporosisPINP, intact pro-collagen type I N-terminal pro-peptidePTH, parathyroid hormoneTMV, Turnover, mineralization, and volumeTRAP5b, tartrate resistant acid phosphatase type 5bX-Ray MicrotomographyμCT, micro computed tomography

Identifiers

PMID35198658
PMCPMC8851083
OpenAlexW4210297789

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.