ArticleIndian dermatology online journal
RegiSCAR DRESS (Drug Reaction with Eosinophilia and Systemic Symptoms) Validation Scoring System and Japanese Consensus Group Criteria for Atypical Drug-Induced Hypersensitivity Syndrome (DiHS): A Comparative Analysis.
Article in Indian dermatology online journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Severe Toxicodermia due to Apalutamide: A Case Report of DRESS in an Elderly Adult.International journal of hematology-oncology and stem cell research · 2026Article
- Evaluation of pediatric patients with drug allergy confirmed by in vivo diagnostic tests.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- The cutaneous mirror: leveraging drug-induced skin phenotypes as early visual risk signals for systemic toxicity, a comprehensive review.Frontiers in drug safety and regulation · 2026Review
- Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Due to Trimethoprim: A Case Report.Cureus · 2025Article
- Carbamazepine-Induced Drug Rash With Eosinophilia and Systemic Symptoms (DRESS) Syndrome.Cureus · 2025Article
- Article
- Empagliflozin-related DRESS syndrome.European heart journal. Case reports · 2025Article
- Accelerated Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome in Response to TMP-SMX: A Case Report.The American journal of case reports · 2025Article
- Concurrent acute interstitial nephritis with acute pyelonephritis in DRESS syndrome: a rare case report.Annals of medicine and surgery (2012) · 2025Article
- Fluconazole-induced drug rash with eosinophilia and systemic symptoms syndrome: a case report.Journal of medical case reports · 2025Article
- Clopidogrel-induced drug-induced hypersensitivity syndrome following percutaneous coronary intervention: a case report of therapeutic dilemma and management strategy.Frontiers in pharmacology · 2025Article
- DRESS Mimicking Flushing Syndrome Associated with Vancomycin: A Case Report.Current drug safety · 2025Article
- Rapid-onset DRESS syndrome secondary to iopamidol contrast media with subsequent syndrome of inappropriate antidiuretic hormone secretion.JAAD case reports · 2024Article
- Evaluation of Anticonvulsant-Induced Leukocytosis: A Review of Evidence for Carbamazepine, Lamotrigine, and Phenobarbital.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2024Review
- ALDRESS: A Retrospective Pilot Study to Develop a Pharmacological Causality Algorithm for Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS).Journal of clinical medicine · 2024Article
- Evaluation of the frequency and characteristics of drug hypersensitivity reactions in hospitalized children: Real life-cohort study.The World Allergy Organization journal · 2024Article
- Case report: Drug reaction with eosinophilia and systemic symptoms (DRESS) induced by ceftazidime in a connective tissue disease (CTD) patient.Frontiers in pharmacology · 2024Article
- Drug reaction with eosinophilia and systemic symptoms syndrome secondary to isoniazid and ethambutol: a case report and literature review.Annals of medicine and surgery (2012) · 2023Article
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Corrections and comments
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Authors and funding
7 authors.
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Abstract
contextDrug reaction with eosinphilia and systemic symptoms (DRESS) and drug-induced hypersensitivity syndrome (DiHS) represent the same spectrum of a drug reaction.
aimsTo compare the clinical profile of patients diagnosed as definite/probable DRESS by the Registry of Severe Cutaneous Adverse Reaction (RegiSCAR) scoring system and as atypical DiHS by Japanese consensus group criteria. SETTINGS AND
designWe did a retrospective study in a tertiary referral center. MATERIALS AND
methodsWe included patients who satisfied the criteria for definite/probable DRESS and/or atypical DiHS and who received inpatient care in our department from January 2011 to December 2018. We compared the clinical and laboratory findings in patients diagnosed by the two criteria. STATISTICAL ANALYSIS: Pearson Chi-square test was used to compare the proportion of patients with severe reactions diagnosed by the RegiSCAR DRESS validation scoring system and the Japanese consensus group criteria.
resultsAmong the 390 case records reviewed, 138 patients could be classified as definite/probable DRESS and/or atypical DiHS. Japanese criteria did not diagnose atypical DiHS in 88/137 (64.2%) patients with definite/probable DRESS. RegiSCAR scoring system made a diagnosis of definite/probable DRESS in 49/50 (98%) patients with atypical DiHS. A total of 58/138 (42%) patients had a severe reaction. RegiSCAR scoring system diagnosed 57/58 (98.3%) patients with severe reaction as definite/probable DRESS. A total of 32/58 (55.2%) patients with severe reactions were diagnosed as atypical DiHS. The difference was statistically significant (<0.001).
conclusionJapanese criteria for atypical DiHS showed reduced sensitivity to diagnose definite/probable DRESS, and this included more than 40% of patients with severe DRESS.
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