Evidence map›Paper›PMID 35198457›Full record

ArticleFrontiers in cellular and infection microbiology2022

The P4 Study: Postpartum Maternal and Infant Faecal Microbiome 6 Months After Hypertensive Versus Normotensive Pregnancy.

Daniella Frances Susic, Leanne Wang, Lynne Margaret Roberts, Michelle Bai, Andrew Gia, Emily McGovern, Xiao-Tao Jiang, Gregory K Davis, Emad El-Omar, Amanda Henry

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Daniella Frances SusicSchool of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Leanne WangFaculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Lynne Margaret RobertsMicrobiome Research Centre, University of New South Wales, Sydney, NSW, Australia.
Michelle BaiFaculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Andrew GiaMicrobiome Research Centre, University of New South Wales, Sydney, NSW, Australia.
Emily McGovernMicrobiome Research Centre, University of New South Wales, Sydney, NSW, Australia.
Xiao-Tao JiangMicrobiome Research Centre, University of New South Wales, Sydney, NSW, Australia.
Gregory K DavisSchool of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Emad El-OmarMicrobiome Research Centre, University of New South Wales, Sydney, NSW, Australia.
Amanda HenrySchool of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
UNSW Sydney · AUSt George Hospital · AUSutherland Hospital · AUThe George Institute for Global Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objective/hypothesisTo explore potential differences in faecal microbiome between women, and their infants, who had normotensive pregnancies (NP) and those who had a hypertensive pregnancy (HP), either gestational hypertension (GH) or preeclampsia (PE).

methodsThis is a sub study of P4 (Postpartum Physiology, Psychology, and Paediatrics Study) and includes 18 mother-infant pairs: 10 NP and 8 HP (HP as defined by blood pressure > 140/90mmHg; of which 6 had PE, and 2 GH), six months postpartum. The participating mothers collected stool samples from themselves and their infants. 16S rRNA V3-V4 amplicons were used to study the faecal microbiome.

resultsThe sample of women and their infants were mostly primiparous ( DISCUSSION: While our findings are at best preliminary, due to the very small sample size, they do suggest that the presence of hypertension in pregnancy may adversely affect the maternal microbiota postpartum, and that of their infants. Further analysis of postpartum microbiome data from future studies will be important to validate these early findings and provide further evidence about the changes in the microbiota in the offspring of women following hypertensive disorders of pregnancy (HDP), including possible links to the causes of long-term cardiovascular disease, the prevalence of which is increased in women who have experienced HDP.

Indexed as

Gastrointestinal MicrobiomeHypertensionBlood PressureChildFemaleHumansInfantPostpartum PeriodPregnancyRNA, Ribosomal, 16SRNA, Ribosomal, 16Shypertensive pregnancyinfancymicrobiomepostpartumpreeclampsiapregnancy

Identifiers

PMID35198457
PMCPMC8860159
OpenAlexW4210272280

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.