Evidence map›Paper›PMID 35197845›Full record

ArticleFrontiers in aging neuroscience2022

Intermittent Theta Burst Stimulation Increases Natural Oscillatory Frequency in Ipsilesional Motor Cortex Post-Stroke: A Transcranial Magnetic Stimulation and Electroencephalography Study.

Qian Ding, Songbin Chen, Jixiang Chen, Shunxi Zhang, Yuan Peng, Yujie Chen, Junhui Chen, Xiaotong Li, Kang Chen, Guiyuan Cai and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.

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  6. Sensory Entrained TMS (seTMS) enhances motor cortex plasticity.bioRxiv : the preprint server for biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Qian DingDepartment of Rehabilitation Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Songbin ChenDepartment of Rehabilitation Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Jixiang ChenDepartment of Rehabilitation Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Shunxi ZhangDepartment of Rehabilitation Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Yuan PengDepartment of Rehabilitation Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Yujie ChenDepartment of Rehabilitation Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Junhui ChenDepartment of Rehabilitation Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Xiaotong LiDepartment of Rehabilitation Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Kang ChenDepartment of Rehabilitation Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Guiyuan CaiDepartment of Rehabilitation Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Guangqing XuDepartment of Rehabilitation Medicine, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yue LanDepartment of Rehabilitation Medicine, Guangzhou First People's Hospital, South China University of Technology, Guangzhou, China.
Guangzhou Medical University · CNGuangzhou First People's Hospital · CNSouth China University of Technology · CNGuangdong Academy of Medical Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIntermittent theta burst stimulation (iTBS) has been widely used as a neural modulation approach in stroke rehabilitation. Concurrent use of transcranial magnetic stimulation and electroencephalography (TMS-EEG) offers a chance to directly measure cortical reactivity and oscillatory dynamics and allows for investigating neural effects induced by iTBS in all stroke survivors including individuals without recordable MEPs. Here, we used TMS-EEG to investigate aftereffects of iTBS following stroke.

methodsWe studied 22 stroke survivors (age: 65.2 ± 11.4 years; chronicity: 4.1 ± 3.5 months) with upper limb motor deficits. Upper-extremity component of Fugl-Meyer motor function assessment and action research arm test were used to measure motor function of stroke survivors. Stroke survivors were randomly divided into two groups receiving either Active or Sham iTBS applied over the ipsilesional primary motor cortex. TMS-EEG recordings were performed at baseline and immediately after Active or Sham iTBS. Time and time-frequency domain analyses were performed for quantifying TMS-evoked EEG responses.

resultsAt baseline, natural frequency was slower in the ipsilesional compared with the contralesional hemisphere (

conclusionsThis is the first study to investigate the acute neural adaptations after iTBS in stroke survivors using TMS-EEG. Our results revealed that natural frequency is altered following stroke which is related to motor impairments. iTBS increases natural frequency in the ipsilesional motor cortex in stroke survivors. Our findings implicate that iTBS holds the potential to normalize natural frequency in stroke survivors, which can be utilized in stroke rehabilitation.

Indexed as

evoked oscillatory responseintermittent theta burst stimulationnatural frequencystroke rehabilitationTMS-EEG

Identifiers

PMID35197845
PMCPMC8859443
OpenAlexW4210855458

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.