ArticleFrontiers in aging neuroscience2022
Early Noise-Induced Hearing Loss Accelerates Presbycusis Altering Aging Processes in the Cochlea.
Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Hearing loss and its association with all-cause and cause-specific mortality: A meta-analysis of cohort studies.PloS one · 2025Pooled it
- Does occupational noise exposure aggravate age-related hearing loss? A population-based study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Association between lifetime noise exposure and audiometric thresholds using the noise exposure structured interview.Scientific reports · 2026Article
- Targeting Sensory Neuropathies Through Neurotrophin-Based Approaches.Cellular and molecular neurobiology · 2026Review
- Predicting hearing loss in noise-exposed petrochemical workers: Influencing factors and a nomogram model.Public health in practice (Oxford, England) · 2026Article
- Prediction of risk of hearing loss by industry noise from cross-sectional and longitudinal data.Communications medicine · 2026Article
- Repurposing Renin-Angiotensin System Drugs for the Treatment of Audiovestibular Disorders.Journal of clinical medicine · 2026Review
- Precision Diagnostics in Age-Related Hearing Loss: Emerging Molecular Biomarkers for Early Detection and Targeted Prevention.International journal of general medicine · 2026Review
- Introducing a translationally relevant mouse model of radiosurgery-induced unilateral hearing loss.Frontiers in neuroscience · 2026Article
- Short-term hearing aid use reduces auditory cortical responses to speech-in-noise listening among older adults with age-related hearing loss.Frontiers in aging neuroscience · 2026Article
- Association of FAS gene polymorphisms with the risk of noise-induced hearing loss in Chinese occupational workers.Frontiers in public health · 2026Article
- Intestinal inflammation and microbiota modulation impact cochlear function: emerging insights in gut-ear axis.Cell communication and signaling : CCS · 2025Article
- Hearing impairment and dementia: cause, catalyst or consequence?Journal of neurology · 2025Review
- A Cross-Sectional Study of the Time of Onset of Hearing Loss in Bus Drivers Following Exposure to Occupational Noise.Journal of audiology & otology · 2025Article
- Review
- Morphological phenotyping of the aging cochlea in inbred C57BL/6N and outbred CD1 mouse strains.Aging cell · 2025Article
- Pathophysiological insights and therapeutic developments in age-related hearing loss: a narrative review.Frontiers in aging neuroscience · 2025Review
- Article
- Alterations of brain network topology and structural-functional connectivity coupling in noise-induced hearing loss based on macroscopic scale.Frontiers in neuroscience · 2025Article
- Beyond the auditory system: cognitive implications of age-related hearing loss.Frontiers in aging neuroscience · 2025Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies identified hearing loss as a risk factor for aging-related processes, including neurodegenerative diseases, as dementia and age-related hearing loss (ARHL). Although the association between hearing impairment in midlife and ARHL has been widely documented by epidemiological and experimental studies, the molecular mechanisms underlying this association are not fully understood. In this study, we used an established animal model of ARHL (C57BL/6 mice) to evaluate if early noise-induced hearing loss (NIHL) could affect the onset or progression of age-related cochlear dysfunction. We found that hearing loss can exacerbate ARHL, damaging sensory-neural cochlear epithelium and causing synaptopathy. Moreover, we studied common pathological markers shared between hearing loss and ARHL, demonstrating that noise exposure can worsen/accelerate redox status imbalance [increase of reactive oxygen species (ROS) production, lipid peroxidation, and dysregulation of endogenous antioxidant response] and vascular dysfunction [increased expression of hypoxia-inducible factor-1alpha (HIF-1α) and vascular endothelial growth factor C (VEGFC)] in the cochlea. Unveiling the molecular mechanisms underlying the link between hearing loss and aging processes could be valuable to identify effective therapeutic strategies to limit the effect of environmental risk factors on age-related diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.