Evidence map›Paper›PMID 35197734›Full record

ArticleSaudi journal of biological sciences2022

Lavanya Nagamalla, J V Shanmukha Kumar, Chintakindi Sanjay, Ali M Alsamhan, Mohammed Rafi Shaik

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi journal of biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lavanya NagamallaDepartment of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, A.P., India.
J V Shanmukha KumarDepartment of Chemistry, Koneru Lakshmaiah Education Foundation, Vaddeswaram, A.P., India.
Chintakindi SanjayIndustrial Engineering Department, College of Engineering, King Saud University, P.O. Box. 800, Riyadh 11451, Saudi Arabia.
Ali M AlsamhanIndustrial Engineering Department, College of Engineering, King Saud University, P.O. Box. 800, Riyadh 11451, Saudi Arabia.
Mohammed Rafi ShaikDepartment of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AXL kinase is an attractive cancer target for drug design and it is involved in different cancers. A set of molecule databases with 1072 secondary metabolites from seaweeds were screened against the AXL kinase active site and eight molecules were shortlisted for further studies. From the docking analysis of the complexes, four molecules GA011, BE005, BC010, and BC005 are showing prominent binging. From the 100 ns of molecular dynamics simulations and ligand-bound complex MM-PBSA free energy analysis, two molecules BC010 (ΔG = -135.38 kJ/mol) and BE005 (ΔG = -141.72 kJ/mol) are showing molecule stability in the active site also showing very strong binding free energies. It suggests these molecules could be the potent molecules for AXL kinase.

Indexed as

AXL kinaseCancer therapyMarine speciesMolecular dynamics simulationsSecondary metabolitesVirtual screening

Identifiers

PMID35197734
PMCPMC8848138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.